MMSE-Präprogressionsrate als potentieller Prädikator des kognitiven und funktionellen Progresses der Alzheimer-Demenz

MMSE-preprogression as a potential predictor of cognitive and functional progress of Alzheimer's disease

by Kerim Gherib
Doctoral thesis
Date of Examination:2017-05-31
Date of issue:2017-05-22
Advisor:Dr. Christian Schmidt
Referee:Prof. Dr. Inga Zerr
Referee:PD Dr. Bernhard Kis
Persistent Address: http://dx.doi.org/10.53846/goediss-6294

 

 

Files in this item

Name:diss veröffentlichen.pdf
Size:2.20Mb
Format:PDF
Description:Dissertation

The following license files are associated with this item:

Abstract

English

For many years studies tried to predict the progress of Alzheimer’s disease (AD), but until finishing this work no examination techniques have reached the clinical stage. The preprogression rate (PPR) was first mentioned by Doody in 2001. Only two more studies mentioned the PPR, one published by Doody in 2010 and another one by Rountree in 2012, with Doody as a coauthor. This work picks up the PPR and applies it to different cognitive and functional scales. The biggest difference between this work and the aforementioned studies is the non-adjustment for covariables, while Doody adjusted for covariables. This work postulates the distinctive connection between the PPR and the covariables. Thus the adjustment for covariables would diminish the effect of the PPR itself. PPR for different scales have been calculated: MMSE, iADL, bADL, GDS, UPDRS and a few selected CERAD-PLUS categories. 107 patients with AD were analyzed, 59 women and 48 men. Patients above 25 MMSE points were classified as AD according to the newest diagnostic criteria proposed by the IWG, which were used as inclusion criteria for the study. Due to multivariate analysis two different groups could be distinguished. Group 0 (MMSE: 0 – 20) progressed contrary to the calculated PPR and group 1 (MMSE: 21 – 30) progressed equivalent to the calculated PPR. PPR for the different scales (iADL, bADL, GDS, UPDRS and a few selected CERAD-PLUS) could not be determined properly and did not have any remarkable correlation.
Keywords: preprogression rate; Alzheimer's disease
 
Statistik