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Zur Rolle der Chorda dorsalis und der Funktion der Dyneine bei der molekularen Rechts-Links-Differenzierung des Säugers

dc.contributor.advisorViebahn, Christoph Prof. Dr.
dc.contributor.authorSchröder, Silke Sabina
dc.date.accessioned2017-06-23T08:23:49Z
dc.date.available2017-07-04T22:50:07Z
dc.date.issued2017-06-23
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0023-3E8A-A
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-6347
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleZur Rolle der Chorda dorsalis und der Funktion der Dyneine bei der molekularen Rechts-Links-Differenzierung des Säugersde
dc.typedoctoralThesisde
dc.title.translatedThe role of the notochord and the function of dyneins in the molecular left-right-differentiation of mammalsde
dc.contributor.refereeGroßhans, Jörg Prof. Dr.
dc.date.examination2017-06-27
dc.description.abstractengLeft-right-differentiation is conserved in all vertebrates, also is the orientation of internal organs defined to either the left or the right side and the viscera are rotated in a certain direction. This implicates a conserved mechanism of regulation. Mutations in axonemal dyneins as well the loss of function experiments lead to dysfunctional cilia and a phenotype of situs inversus in human and model organisms, and cilia are said to be critical for the left-right-differentiation in several vertebrates. In rabbits we found long monocilia on the ventral side of the notochord, which are required for the notochordal leftward flow. This structural feature cannot be shown in all animals, e.g. the chick and the pig embryos show a lack of cilia on their early notochord, which is also covered by the endoderm. Notochord and primitive node show great morphologic similarities in chick, pig, rabbit, mouse and human embryos, but we found also functionally important differences concerning the ventral covering of the notochord during the embryonic development. A common structure in all species examined, is the subchordal mesoderm, a mesenchymal structure ventral to the posterior notochord. In addition we studied expression of axonemal dyneins in rabbit and pig embryos. While in the pig the expression in the notochord was not detectable, rabbit embryos reveal a symmetric expression of dynein 5, 9 and 11 in the posterior notochord matching published data in xenopus and suggesting involvement of axonemal dyneins in the left-right symmetry breaking and differentiation. Our data indicates that ciliary flow is not the universal mechanism of left-right symmetry breaking shared by all vertebrates and suggests that another mechanism has to be postulated presuming a conserved regulatory mechanism of left-right-differentiation and symmetry breaking.de
dc.contributor.coRefereeMansouri, Ahmed Prof. Dr.
dc.subject.gerChorda dorsalisde
dc.subject.gerKaninchende
dc.subject.gerSäugerde
dc.subject.gerEmbryode
dc.subject.gerRechts-Links-Differenzierungde
dc.subject.gersubchordales Mesodermde
dc.subject.gerEntwicklungde
dc.subject.geraxonemale Dyneinede
dc.subject.gerSymmetriebrechungde
dc.subject.gerGastrulationde
dc.subject.engnotochordde
dc.subject.engrabbitde
dc.subject.engmammalde
dc.subject.engembryode
dc.subject.engleft-right-differentiationde
dc.subject.engsubchordal mesodermde
dc.subject.engdevelopmentde
dc.subject.enggastrulationde
dc.subject.engciliary flowde
dc.subject.engaxonemal dyneinde
dc.subject.engsymmetry breakingde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0023-3E8A-A-8
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullAnatomie / Histologie / Embryologie / Medizinische Anthropologie - Allgemein- und Gesamtdarstellungen (PPN619875208)de
dc.description.embargoed2017-07-04
dc.identifier.ppn89090930X


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