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dc.contributor.advisor Viebahn, Christoph Prof. Dr.
dc.contributor.author Schröder, Silke Sabina
dc.date.accessioned 2017-06-23T08:23:49Z
dc.date.available 2017-07-04T22:50:07Z
dc.date.issued 2017-06-23
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0023-3E8A-A
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Zur Rolle der Chorda dorsalis und der Funktion der Dyneine bei der molekularen Rechts-Links-Differenzierung des Säugers de
dc.type doctoralThesis de
dc.title.translated The role of the notochord and the function of dyneins in the molecular left-right-differentiation of mammals de
dc.contributor.referee Großhans, Jörg Prof. Dr.
dc.date.examination 2017-06-27
dc.description.abstracteng Left-right-differentiation is conserved in all vertebrates, also is the orientation of internal organs defined to either the left or the right side and the viscera are rotated in a certain direction. This implicates a conserved mechanism of regulation. Mutations in axonemal dyneins as well the loss of function experiments lead to dysfunctional cilia and a phenotype of situs inversus in human and model organisms, and cilia are said to be critical for the left-right-differentiation in several vertebrates. In rabbits we found long monocilia on the ventral side of the notochord, which are required for the notochordal leftward flow. This structural feature cannot be shown in all animals, e.g. the chick and the pig embryos show a lack of cilia on their early notochord, which is also covered by the endoderm. Notochord and primitive node show great morphologic similarities in chick, pig, rabbit, mouse and human embryos, but we found also functionally important differences concerning the ventral covering of the notochord during the embryonic development. A common structure in all species examined, is the subchordal mesoderm, a mesenchymal structure ventral to the posterior notochord. In addition we studied expression of axonemal dyneins in rabbit and pig embryos. While in the pig the expression in the notochord was not detectable, rabbit embryos reveal a symmetric expression of dynein 5, 9 and 11 in the posterior notochord matching published data in xenopus and suggesting involvement of axonemal dyneins in the left-right symmetry breaking and differentiation. Our data indicates that ciliary flow is not the universal mechanism of left-right symmetry breaking shared by all vertebrates and suggests that another mechanism has to be postulated presuming a conserved regulatory mechanism of left-right-differentiation and symmetry breaking. de
dc.contributor.coReferee Mansouri, Ahmed Prof. Dr.
dc.subject.ger Chorda dorsalis de
dc.subject.ger Kaninchen de
dc.subject.ger Säuger de
dc.subject.ger Embryo de
dc.subject.ger Rechts-Links-Differenzierung de
dc.subject.ger subchordales Mesoderm de
dc.subject.ger Entwicklung de
dc.subject.ger axonemale Dyneine de
dc.subject.ger Symmetriebrechung de
dc.subject.ger Gastrulation de
dc.subject.eng notochord de
dc.subject.eng rabbit de
dc.subject.eng mammal de
dc.subject.eng embryo de
dc.subject.eng left-right-differentiation de
dc.subject.eng subchordal mesoderm de
dc.subject.eng development de
dc.subject.eng gastrulation de
dc.subject.eng ciliary flow de
dc.subject.eng axonemal dynein de
dc.subject.eng symmetry breaking de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3E8A-A-8
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Anatomie / Histologie / Embryologie / Medizinische Anthropologie - Allgemein- und Gesamtdarstellungen (PPN619875208) de
dc.description.embargoed 2017-07-04
dc.identifier.ppn 89090930X

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