Grey Matter Perfusion in Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis
by Alina Freing
Date of Examination:2017-10-10
Date of issue:2017-09-06
Advisor:Prof. Dr. Michael Knauth
Referee:Prof. Dr. Michael Knauth
Referee:Prof. Dr. Martin Weber
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Description:Dissertation (Online-Version)
Abstract
English
This study compares magnetic resonance imaging-derived cerebral grey matter perfusion characteristics in patients diagnosed with clinically isolated syndrome and patients diagnosed with relapsing-remitting multiple sclerosis. Normalized brain volume and the Expanded Disability Status Scale were used as markers of disease severity. There is no difference between both subject subgroups with respect to perfusion parameters in any of the analysed grey matter regions in a simple group comparison. However, the results from the simultaneous correlation analysis indicate that there is a difference in local perfusion between the two groups of patients. This study therefore suggests that simply group comparisons are not a suitable tool to analyse regional perfusion metrics. In summary, the results of this study suggest that the underlying mechanism responsible for hemodynamic changes in clinically isolated syndrome and relapsing-remitting multiple sclerosis is diffuse rather than focal and is subject to some sort of (temporal) evolution.
Keywords: Multiple Sclerosis; clinically isolated syndrome; MRI perfusion; grey matter perfusion