| dc.contributor.advisor | Zabel, Markus Prof. Dr. | |
| dc.contributor.author | Wallisch, Nora | |
| dc.date.accessioned | 2017-09-06T10:20:36Z | |
| dc.date.available | 2017-09-27T22:50:07Z | |
| dc.date.issued | 2017-09-06 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0023-3EEF-8 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6459 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Einfluss von Ranolazin und Flunarizin in Kombination mit d-Sotalol auf getriggerte Arrhythmien im isolierten Kaninchenherzen | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Effects of ranolazine and flunarizine on torsades de pointes tachycardias in a healthy isolated rabbit heart model | de |
| dc.contributor.referee | Lutz, Susanne Prof. Dr. | |
| dc.date.examination | 2017-09-20 | |
| dc.description.abstracteng | Torsades de pointes (TdP) tachycardias are triggered, polymorphic ventricular arrhythmias
arising from early afterdepolarizations (EADs) and increased dispersion of repolarization.
Ranolazine is a new agent which reduces pathologically elevated late INa but also
IKr. Aim of this study was to evaluate the effects of ranolazine in a validated isolated Langendorff-
perfused rabbit heart model. TdP was reproducibly induced with d-sotalol
(10
4 mol/L) and low potassium (K) (1.0 mmol/L for 5 min, pacing at CL 1000 ms). In 10
hearts, ECG and 8 epi- and endocardial monophasic action potentials were recorded. Action
potential duration (APD) was measured at 90% repolarization and dispersion defined as
APD max–min. Results: D-sotalol prolonged APD90 and increased dispersion of APD90,
simultaneously causing EADs and induction of TdP. The combination of d-sotalol and two
concentrations of ranolazine did not increase dispersion of ventricular APD90 as compared
to vehicle. Ranolazine at 5 lmol/L did not cause additional induction of EADs and/or TdP
but also did not significantly suppress arrhythmogenic triggers. The higher concentration of
ranolazine (10 lmol/L) in combination with d-sotalol caused further prolongation of
APD90, at the same time reduction in APD90 dispersion. In parallel, the incidence of EADs
was reduced and an antitorsadogenic effect was seen. In the healthy isolated
rabbit heart (where late INa is not elevated), ranolazine does not cause proarrhythmia but
exerts antiarrhythmic effects in a dose-dependent manner against d-sotalol/low K-induced
TdP. This finding—despite additional APD prolongation—supports the safety of a combined
use of both drugs and merits clinical investigation. | de |
| dc.contributor.coReferee | Schön, Margarete Prof. Dr. | |
| dc.subject.eng | ranolazine | de |
| dc.subject.eng | flunarizine | de |
| dc.subject.eng | torsade de pointes | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3EEF-8-1 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2017-09-27 | |
| dc.identifier.ppn | 1002724511
1000147606 | |