• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Naturwissenschaften, Mathematik und Informatik
  • Fakultät für Chemie (inkl. GAUSS)
  • Item View
  •   Home
  • Naturwissenschaften, Mathematik und Informatik
  • Fakultät für Chemie (inkl. GAUSS)
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Small Molecule Activation of Copper and Iron Complexes with Bis(oxazoline) Ligands

by Vandana Esther Goswami
Doctoral thesis
Date of Examination:2016-10-17
Date of issue:2017-09-22
Advisor:Prof. Dr. Franc Meyer
Referee:Prof. Dr. Franc Meyer
Referee:Dr. Inke Siewert
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-6498

 

 

Files in this item

Name:Vandana Esther Goswami_PhD Thesis.pdf
Size:7.47Mb
Format:PDF
Description:V E Goswami PhD thesis
ViewOpen

The following license files are associated with this item:


Abstract

English

This work describes small molecule activation by copper and iron complexes with structurally and electronically modified bis(oxazoline) (BOX) ligand systems, focusing on dioxygen and nitric oxide as substrates. Dioxygen activation at low temperatures by copper(I) complexes with neutral BOX scaffolds generated the side on peroxo dicopper(II) systems that resemble the intermediates found in type III copper proteins, whereas those complexes with an anionic BOX-derived scaffold generated the bis(µ-oxido) dicopper(III) species. The bis(µ-oxido) system has recently been proposed as an active intermediate of pMMO. All complexes have been comprehensively characterized in solid state and solution, including single crystal X-ray crystallographic structure determination for representative examples, and the intermediates were screened for substrate reactivity. Moreover, triggered by protonation/deprotonation reactions, it was possible to interconvert the side-on peroxo dicopper(II) and bis(µ-oxido) dicopper(III) systems. The reaction of iron(II) BOX complexes with nitric oxide successfully generated a dinitrosyl iron complex that was isolated and characterized as well. In conclusion, BOX ligands that have been termed as a privileged ligand class in the field of asymmetric catalysis, have proved themselves to be useful in the field of bioinorganic chemistry as well.
Keywords: small molecule activation; type III copper proteins; side-on peroxo dicopper(II); bis mu-oxido dicopper(III); nitric oxide; dinitrosyl iron complex; bis(oxazoline)
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]