| dc.contributor.advisor | Neef, Andreas Dr. | |
| dc.contributor.author | Keith, Tūreiti | |
| dc.date.accessioned | 2017-10-10T10:14:01Z | |
| dc.date.available | 2017-10-10T10:14:01Z | |
| dc.date.issued | 2017-10-10 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0023-3F22-C | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-6506 | |
| dc.language.iso | eng | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 571.4 | de |
| dc.title | On the Speed of Neuronal Populations | de |
| dc.type | doctoralThesis | de |
| dc.contributor.referee | Stühmer, Walter Prof. Dr. | |
| dc.date.examination | 2017-03-07 | |
| dc.description.abstracteng | This thesis presents novel results in the areas of closed loop electrophysiology and neuronal population coding. This work begins by presenting the first known attempt to control the spike rate of a neuron or neurons using a feedback controller that drives a stochastic photostimulus. Using this controller, in vitro experiments were performed that look into the response of a population of cortical neurons to subtle changes in the mean of a correlated, stochastic photostimulus. This work then presents a numerical examination of how stimuli targeting specific elements of a neuron's structure, referred to as "subcellular targeting," affect the response speed of the population, the action potential onset of its constituent neurons and their effective passive bandwidth. The results presented here demonstrate that it is indeed possible to regulate the spike rate of a neuron or neurons using a feedback controller that scales the mean and variance of a correlated, stochastic photostimulus. Furthermore, using this controller, trial-based experiments were implemented in the laboratory. These demonstrate that an in vitro population of cortical neurons can provide robust albeit slow responses to subtle changes in the mean of a correlated, stochastic photostimulus. Finally, in numerical experiments, mean modulated, correlated, stochastic photostimuli were applied to either the entire cell, the soma or the basal dendrites of a morphologically realistic constituent
neuron. The results show that this subcellular targeting of constituents produces a faster population response when the soma is targeted, followed by the basal dendritic then the global target. Although a strong statistical argument is difficult to make, the results do suggest congruent increases in the response speed of a neuronal population under subcellular targeting, the onset rapidness of its constituent neurons and their passive bandwidths. | de |
| dc.contributor.coReferee | Wolf, Fred Prof. Dr. | |
| dc.contributor.thirdReferee | Enderlein, Jörg Prof. Dr. | |
| dc.contributor.thirdReferee | Parlitz, Ulrich Prof. Dr. | |
| dc.contributor.thirdReferee | Wörgötter, Florentin Prof. Dr. | |
| dc.subject.eng | closed loop | de |
| dc.subject.eng | optogenetics | de |
| dc.subject.eng | population response | de |
| dc.subject.eng | pid | de |
| dc.subject.eng | targeted stimulus | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3F22-C-4 | |
| dc.affiliation.institute | Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB) | de |
| dc.subject.gokfull | Biologie (PPN619462639) | de |
| dc.identifier.ppn | 1002330343 | |