Interaktion des NaDC3 und des NaCT mit Carbaglu, einem Medikament zur Behandlung der Hyperammonämie

Schwob, Elisabeth

dc.contributor.advisor	Burckhardt, Birgitta-Christina Prof. Dr.
dc.contributor.author	Schwob, Elisabeth
dc.date.accessioned	2017-10-27T07:12:58Z
dc.date.available	2017-12-12T23:50:05Z
dc.date.issued	2017-10-27
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-3F49-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-6552
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Interaktion des NaDC3 und des NaCT mit Carbaglu, einem Medikament zur Behandlung der Hyperammonämie	de
dc.type	doctoralThesis	de
dc.title.translated	Interaction of Carbaglu, a drug for treating hyperammonemia, with the transporters NaDC3 and NaCT	de
dc.contributor.referee	Burckhardt, Birgitta-Christina Prof. Dr.
dc.date.examination	2017-12-05
dc.description.abstracteng	Primary or secondary N-acetylglutamate synthase (NAGS) deficiency leads to the reduction of N-acetylglutamate (NAG), the natural activator of the urea cycle. It results in hyperammonemia. Hyperammonemic crises can be life-threatening. Carbaglu administered orally can normalize elevated blood ammonia levels. Its active agent N-carbamoylglutamate (NCG), a structural and stabile analog of NAG, can reactivate the urea cycle. The renal clearance of NCG suggests active renal secretion. NCG was identified as a high-affinity substrate of the sodium-dependent dicarboxylate transporter NaDC3. The addition of NCG to Xenopus oocytes expressing human NaDC3 protein during two-electrode voltage clamp experiments conducted a sodium-dependent inward current with a Michaelis-Menten constant (Km) around its plasma level. As the transporter is found on the basolateral membranes in renal proximal tubule cells it can be therefore assumed that it mediates the first step of glomerular secretion of NCG. In NaCT-expressing oocytes NCG did not induce measurable currents.	de
dc.contributor.coReferee	Asif, Abdul Rahman Prof. Dr.
dc.subject.eng	hyperammonemia	de
dc.subject.eng	N-acetylglutamate synthase	de
dc.subject.eng	Carbaglu	de
dc.subject.eng	N-carbamylglutamate	de
dc.subject.eng	urea cycle disorders	de
dc.subject.eng	NaDC3	de
dc.subject.eng	SLC13A3	de
dc.subject.eng	SLC13A5	de
dc.subject.eng	NaCT	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-3F49-5-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2017-12-12
dc.identifier.ppn	1002331056

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Human- und Zahnmedizin [2871]

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