C-H and C-C Activation by Cobalt and Ruthenium Catalysis
Marc Philipp Moselage
Doctoral thesis
Date of Examination:
2017-11-15
Date of issue:
2017-12-18
Advisor:
Ackermann, Lutz Prof. Dr.
Referee:
Ackermann, Lutz Prof. Dr.
Referee:
Meyer, Franc Prof. Dr.
Referee:
Stalke, Dietmar Prof. Dr.
Referee:
Alcarazo, Manuel Prof. Dr.
Referee:
Das, Shoubhik Dr.
Referee:
Thomas, Franziska Dr.
Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0023-3FB2-6
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Abstract
English
The thesis contents methods for the selective activation and functionalization of C–H and C–C bonds, among the most abundant bonds in organic molecules. In particular, earth-abundant and cost-effective cobalt complexes were utilized for C–H activation reactions, namely C¬–H alkenylation with alkenyl esters and C–H allylation with allyl esters. Furthermore, the concept of cobalt-catalyzed C–H activation could be applied in the synthesis of indoles, as an important class of heterocycles. Apart from C–H activation, a methodology of the functionalization of C–C bonds was discovered using ruthenium catalysis. In this project, a C–C arylation in a decarboxylative and decarbamoylative fashion was accomplished. This was extended to a decarboxylative alkylation by C–C and C–C/C–H bond cleavage.
Keywords: C-H Activation; C-C Activation; Cobalt; Ruthenium; Alkenylation; Allylation; Indole Synthesis; Arylation; meta-selectivity
