Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms

Untersuchung struktureller zerebraler Alterationen bei Patienten mit idiopathisch-generalisierter Epilepsie unter besonderer Berücksichtigung des Janz-Syndroms

Investigation of structural cerebral alterations in patients with idiopathic-generalized epilepsy with special emphasis on the Janz syndrome

Christine Diederich

Doctoral thesis

Date of Examination: 2015-10-07

Date of issue: 2015-09-30

Advisor: Focke, Niels K. PD Dr.

Referee: Paulus, Walter Prof. Dr.

Referee: Dechent, Peter PD Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0023-9633-F

Files in this item

Name: CD -Online Version.pdf

Size: 1,4 MB

Format: PDF

View/Open

The following license files are associated with this item:

Creative Commons

Abstract

English

The aim of this doctoral thesis was to investigate (micro-) structural alterations of the brain in patients with idiopathic-generalized epilepsy. 25 patients, subdivided in IGE (13) and in the subclass juvenile myoclonic epilepsy (JME, 12), as well as 44 healthy controls were scanned at a 3T MRI-Scanner at the MR Research Group Göttingen with conventional and new MRI-protocols (T1-weighted images, DTI, T1 Relaxometry and semi-quantitative magnetization transfer mapping). Using TBSS for the DTI data, a comparison between patients and healthy controls shows large changes in white matter tracts (FA reductions and MD increases). Voxel-based morphometry of the T1-weighted images, T1 Relaxometry and MT-mapping from 13 patients with IGE and 11 patients with JME compared to 38 controls does not detect significant alterations.

Keywords: JME; IGE; TBSS; VBM; MRI