• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Optical characterization of ligand-induced staining of olfactory receptor neurons in Xenopus laevis

by Nwadiuto Amara Mgbor
Doctoral thesis
Date of Examination:2015-09-30
Date of issue:2015-10-07
Advisor:Prof. Dr. Dr. Detlev Schild
Referee:PD Dr. Alexander Meyer
Referee:Prof. Dr. Martin Oppermann
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-5297

 

 

Files in this item

Name:thesis amara 23.08.2015.2.pdf
Size:1.35Mb
Format:PDF
ViewOpen

The following license files are associated with this item:


Abstract

English

This thesis aimed at investigating ligand-induced staining (LIS) as a new labelling technique to visualize ORN subpopulation in larval X.l. In the course of this study, it was at first validated that LIS is a suitable technique for this experimental model animal. Secondly, tests carried out with forskolin furthermore revealed that the observed staining does not occur via activated cAMP/CNG channels. To generate first evidence that an odorant-induced, receptor-mediated endocytosis could be a plausible explanation for the observed staining, a temperature experiment was conducted, knowing that a decrease in temperature affects receptor-mediated endocytosis in sensory cells of vertebrates. As a decrease in staining efficiency was observed in these experiments, in summary it can be hypothesized that, presumably based on an adaption mechanism, a receptor-mediated endocytosis is the reason for the observed ligand-induced staining.
Keywords: Xenopus laevis; ligand-induced endocytosis
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]