dc.contributor.advisor | Schild, Detlev Prof. Dr. Dr. | |
dc.contributor.author | Mgbor, Nwadiuto Amara | |
dc.date.accessioned | 2015-10-07T09:20:47Z | |
dc.date.available | 2015-10-07T09:20:47Z | |
dc.date.issued | 2015-10-07 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0023-963E-A | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5297 | |
dc.language.iso | eng | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Optical characterization of ligand-induced staining of olfactory receptor neurons in Xenopus laevis | de |
dc.type | doctoralThesis | de |
dc.contributor.referee | Meyer, Alexander PD Dr. | |
dc.date.examination | 2015-09-30 | |
dc.description.abstracteng | This thesis aimed at investigating ligand-induced staining (LIS) as a new labelling technique to visualize ORN subpopulation in larval X.l. In the course of this study, it was at first validated that LIS is a suitable technique for this experimental model animal. Secondly, tests carried out with forskolin furthermore revealed that the observed staining does not occur via activated cAMP/CNG channels. To generate first evidence that an odorant-induced, receptor-mediated endocytosis could be a plausible explanation for the observed staining, a temperature experiment was conducted, knowing that a decrease in temperature affects receptor-mediated endocytosis in sensory cells of vertebrates. As a decrease in staining efficiency was observed in these experiments, in summary it can be hypothesized that, presumably based on an adaption mechanism, a receptor-mediated endocytosis is the reason for the observed ligand-induced staining. | de |
dc.contributor.coReferee | Oppermann, Martin Prof. Dr. | |
dc.subject.eng | Xenopus laevis | de |
dc.subject.eng | ligand-induced endocytosis | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0023-963E-A-4 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Medizin (PPN619874732) | de |
dc.subject.gokfull | Neuroanatomie, Neurophysiologie, Neuropathologie (PPN619876255) | de |
dc.identifier.ppn | 836298985 | |