Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen

Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen

Effects of the novel CaMKII inhibitor SMP-114 on diastolic SR Ca2+ leak and EC coupling in isolated cardiomyocites

Christian Mann

Doctoral thesis

Date of Examination: 2015-10-28

Date of issue: 2015-10-28

Advisor: Maier, Lars S. Prof. Dr.

Referee: Maier, Lars S. Prof. Dr.

Referee: Dellas, Claudia Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-0023-9663-5

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Abstract

English

The effects of the novel CaMKII inhibitor on Ca2+ handling and EC coupling of isolated murine cardiomyocites were evaluated using epifluorescence and confocal microscopy. SMP-114 warranted a significant reduction in diastolic Ca2+ loss from the SR and spontaneous Ca2+ release events. EC coupling and contractility was not significantly altered in most measurements.

Keywords: EC coupling; CaMKII; heart failure; ca2+ leak; SMP-114; AIP; Ca2+ Sparls; SCE events; diastolic Ca2+ loss; SR Ca2+ loss