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dc.contributor.advisor Maier, Lars S. Prof. Dr.
dc.contributor.author Mann, Christian
dc.date.accessioned 2015-10-28T10:10:26Z
dc.date.available 2015-11-04T23:50:05Z
dc.date.issued 2015-10-28
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-0023-9663-5
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen de
dc.type doctoralThesis de
dc.title.translated Effects of the novel CaMKII inhibitor SMP-114 on diastolic SR Ca2+ leak and EC coupling in isolated cardiomyocites de
dc.contributor.referee Maier, Lars S. Prof. Dr.
dc.date.examination 2015-10-28
dc.description.abstracteng The effects of the novel CaMKII inhibitor on Ca2+ handling and EC coupling of isolated murine cardiomyocites were evaluated using epifluorescence and confocal microscopy. SMP-114 warranted a significant reduction in diastolic Ca2+ loss from the SR and spontaneous Ca2+ release events. EC coupling and contractility was not significantly altered in most measurements. de
dc.contributor.coReferee Dellas, Claudia Prof. Dr.
dc.subject.eng EC coupling de
dc.subject.eng CaMKII de
dc.subject.eng heart failure de
dc.subject.eng ca2+ leak de
dc.subject.eng SMP-114 de
dc.subject.eng AIP de
dc.subject.eng Ca2+ Sparls de
dc.subject.eng SCE events de
dc.subject.eng diastolic Ca2+ loss de
dc.subject.eng SR Ca2+ loss de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9663-5-4
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Kardiologie (PPN619875755) de
dc.subject.gokfull Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747) de
dc.description.embargoed 2015-11-04
dc.identifier.ppn 837983371

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