dc.contributor.advisor | Maier, Lars S. Prof. Dr. | |
dc.contributor.author | Mann, Christian | |
dc.date.accessioned | 2015-10-28T10:10:26Z | |
dc.date.available | 2015-11-04T23:50:05Z | |
dc.date.issued | 2015-10-28 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0023-9663-5 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5326 | |
dc.language.iso | deu | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen | de |
dc.type | doctoralThesis | de |
dc.title.translated | Effects of the novel CaMKII inhibitor SMP-114 on diastolic SR Ca2+ leak and EC coupling in isolated cardiomyocites | de |
dc.contributor.referee | Maier, Lars S. Prof. Dr. | |
dc.date.examination | 2015-10-28 | |
dc.description.abstracteng | The effects of the novel CaMKII inhibitor on Ca2+ handling and EC coupling of isolated murine cardiomyocites were evaluated using epifluorescence and confocal microscopy. SMP-114 warranted a significant reduction in diastolic Ca2+ loss from the SR and spontaneous Ca2+ release events. EC coupling and contractility was not significantly altered in most measurements. | de |
dc.contributor.coReferee | Dellas, Claudia Prof. Dr. | |
dc.subject.eng | EC coupling | de |
dc.subject.eng | CaMKII | de |
dc.subject.eng | heart failure | de |
dc.subject.eng | ca2+ leak | de |
dc.subject.eng | SMP-114 | de |
dc.subject.eng | AIP | de |
dc.subject.eng | Ca2+ Sparls | de |
dc.subject.eng | SCE events | de |
dc.subject.eng | diastolic Ca2+ loss | de |
dc.subject.eng | SR Ca2+ loss | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9663-5-4 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Kardiologie (PPN619875755) | de |
dc.subject.gokfull | Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747) | de |
dc.description.embargoed | 2015-11-04 | |
dc.identifier.ppn | 837983371 | |