Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen

Mann, Christian

dc.contributor.advisor	Maier, Lars S. Prof. Dr.
dc.contributor.author	Mann, Christian
dc.date.accessioned	2015-10-28T10:10:26Z
dc.date.available	2015-11-04T23:50:05Z
dc.date.issued	2015-10-28
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-9663-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5326
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen	de
dc.type	doctoralThesis	de
dc.title.translated	Effects of the novel CaMKII inhibitor SMP-114 on diastolic SR Ca2+ leak and EC coupling in isolated cardiomyocites	de
dc.contributor.referee	Maier, Lars S. Prof. Dr.
dc.date.examination	2015-10-28
dc.description.abstracteng	The effects of the novel CaMKII inhibitor on Ca2+ handling and EC coupling of isolated murine cardiomyocites were evaluated using epifluorescence and confocal microscopy. SMP-114 warranted a significant reduction in diastolic Ca2+ loss from the SR and spontaneous Ca2+ release events. EC coupling and contractility was not significantly altered in most measurements.	de
dc.contributor.coReferee	Dellas, Claudia Prof. Dr.
dc.subject.eng	EC coupling	de
dc.subject.eng	CaMKII	de
dc.subject.eng	heart failure	de
dc.subject.eng	ca2+ leak	de
dc.subject.eng	SMP-114	de
dc.subject.eng	AIP	de
dc.subject.eng	Ca2+ Sparls	de
dc.subject.eng	SCE events	de
dc.subject.eng	diastolic Ca2+ loss	de
dc.subject.eng	SR Ca2+ loss	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9663-5-4
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Kardiologie (PPN619875755)	de
dc.subject.gokfull	Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747)	de
dc.description.embargoed	2015-11-04
dc.identifier.ppn	837983371

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