Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action

Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action

Miglierini, Petra

Dissertation

Angenommen am: 2014-08-20

Erschienen: 2014-09-30

Betreuer: Wolff, Hendrik PD Dr.

Gutachter: Virsik-Köpp, Patricia Prof. Dr.

Gutachter: Mausberg, Rainer Prof. Dr.

Zum Verlinken/Zitieren: http://hdl.handle.net/11858/00-1735-0000-0023-98EC-1

Dateien

Name: Miglierini-P_doktor-arbeit1.pdf

Größe: 996,3 KB

Format: PDF

Öffnen

Lizenzbestimmungen:

Creative Commons Lizenz

Zusammenfassung

Englisch

Statins, as lipid-lowering agents, were described to possess an anti-cancer potential. For this reason, in vitro effect of combined treatment by lovastatin and irradiation was explored in order to find a radiosensitizing or radioprotective effect. This was tested on various human tumour (ZMK-1, A549, MO59K, MO59J) and normal tissue cell lines (HUVEC, HaCaT, fibroblasts). Effect of combined treatment (irradiation-lovastatin-monoclonal antibodies) was examined as well using colony formation assays, viability assays, Western blot and reporter assays.

Keywords: lovastatin; in vitro; irradiation