Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action

by Petra Miglierini
Doctoral thesis
Date of Examination:2014-08-20
Date of issue:2014-09-30
Advisor:PD Dr. Hendrik Wolff
Referee:Prof. Dr. Patricia Virsik-Köpp
Referee:Prof. Dr. Rainer Mausberg
Persistent Address: http://dx.doi.org/10.53846/goediss-4708

 

 

Files in this item

Name:Miglierini-P_doktor-arbeit1.pdf
Size:996.Kb
Format:PDF

The following license files are associated with this item:

Abstract

English

Statins, as lipid-lowering agents, were described to possess an anti-cancer potential. For this reason, in vitro effect of combined treatment by lovastatin and irradiation was explored in order to find a radiosensitizing or radioprotective effect. This was tested on various human tumour (ZMK-1, A549, MO59K, MO59J) and normal tissue cell lines (HUVEC, HaCaT, fibroblasts). Effect of combined treatment (irradiation-lovastatin-monoclonal antibodies) was examined as well using colony formation assays, viability assays, Western blot and reporter assays.
Keywords: lovastatin; in vitro; irradiation
 
Statistik