Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action
von Petra Miglierini
Datum der mündl. Prüfung:2014-08-20
Betreuer:PD Dr. Hendrik Wolff
Gutachter:Prof. Dr. Patricia Virsik-Köpp
Gutachter:Prof. Dr. Rainer Mausberg
EnglischStatins, as lipid-lowering agents, were described to possess an anti-cancer potential. For this reason, in vitro effect of combined treatment by lovastatin and irradiation was explored in order to find a radiosensitizing or radioprotective effect. This was tested on various human tumour (ZMK-1, A549, MO59K, MO59J) and normal tissue cell lines (HUVEC, HaCaT, fibroblasts). Effect of combined treatment (irradiation-lovastatin-monoclonal antibodies) was examined as well using colony formation assays, viability assays, Western blot and reporter assays.
Keywords: lovastatin; in vitro; irradiation