dc.contributor.advisor | Wolff, Hendrik PD Dr. | |
dc.contributor.author | Miglierini, Petra | |
dc.date.accessioned | 2014-09-30T09:05:24Z | |
dc.date.available | 2014-09-30T09:05:24Z | |
dc.date.issued | 2014-09-30 | |
dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0023-98EC-1 | |
dc.identifier.uri | http://dx.doi.org/10.53846/goediss-4708 | |
dc.language.iso | eng | de |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 610 | de |
dc.title | Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action | de |
dc.type | doctoralThesis | de |
dc.contributor.referee | Virsik-Köpp, Patricia Prof. Dr. | |
dc.date.examination | 2014-08-20 | |
dc.description.abstracteng | Statins, as lipid-lowering agents, were described to possess an anti-cancer potential. For this reason, in vitro effect of combined treatment by lovastatin and irradiation was explored in order to find a radiosensitizing or radioprotective effect. This was tested on various human tumour (ZMK-1, A549, MO59K, MO59J) and normal tissue cell lines (HUVEC, HaCaT, fibroblasts). Effect of combined treatment (irradiation-lovastatin-monoclonal antibodies) was examined as well using colony formation assays, viability assays, Western blot and reporter assays. | de |
dc.contributor.coReferee | Mausberg, Rainer Prof. Dr. | |
dc.subject.eng | lovastatin | de |
dc.subject.eng | in vitro | de |
dc.subject.eng | irradiation | de |
dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0023-98EC-1-0 | |
dc.affiliation.institute | Medizinische Fakultät | de |
dc.subject.gokfull | Medizin (PPN619874732) | de |
dc.identifier.ppn | 797782656 | |