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Experimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of action

dc.contributor.advisorWolff, Hendrik PD Dr.
dc.contributor.authorMiglierini, Petra
dc.date.accessioned2014-09-30T09:05:24Z
dc.date.available2014-09-30T09:05:24Z
dc.date.issued2014-09-30
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0023-98EC-1
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-4708
dc.language.isoengde
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc610de
dc.titleExperimental study of the combined effect of irradiation, lovastatin, and monoclonal antibodies on tumour and normal tissue cell lines. Its genesis and mechanisms of actionde
dc.typedoctoralThesisde
dc.contributor.refereeVirsik-Köpp, Patricia Prof. Dr.
dc.date.examination2014-08-20
dc.description.abstractengStatins, as lipid-lowering agents, were described to possess an anti-cancer potential. For this reason, in vitro effect of combined treatment by lovastatin and irradiation was explored in order to find a radiosensitizing or radioprotective effect. This was tested on various human tumour (ZMK-1, A549, MO59K, MO59J) and normal tissue cell lines (HUVEC, HaCaT, fibroblasts). Effect of combined treatment (irradiation-lovastatin-monoclonal antibodies) was examined as well using colony formation assays, viability assays, Western blot and reporter assays.de
dc.contributor.coRefereeMausberg, Rainer Prof. Dr.
dc.subject.englovastatinde
dc.subject.engin vitrode
dc.subject.engirradiationde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0023-98EC-1-0
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.identifier.ppn797782656


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