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Localized Proton Magnetic Resonance Spectroscopy of Mouse Brain In Vivo at High Magnetic Field Strength

dc.contributor.advisorHofsäss, Hans Prof. Dr.
dc.contributor.authorAbaei Tafresh, Alireza
dc.titleLocalized Proton Magnetic Resonance Spectroscopy of Mouse Brain In Vivo at High Magnetic Field Strengthde
dc.contributor.refereeHofsäss, Hans Prof. Dr.
dc.subject.gokPhysik (PPN621336750)de
dc.description.abstractengThis work describes the implementation and optimization of single-voxel proton magnetic resonance spectroscopy for absolute quantification of regional metabolite concentration in mouse brain in vivo at 9.4 T. Optimized scheme of localized shimming, water suppression, and outer-volume-suppression enables a reliable detection of critical metabolite signals. Volume-of-interest localization technique is optimized for 10 different brain regions, where absolute concentrations of 16 different metabolites are determined. No partial volume effect of the cerebrospinal fluid is observed. Measurement of T1 and T2 relaxation times ensures an accurate quantification of metabolite concentrations with regard to the signal attenuation and the water content of brain tissue in vivo. Interestingly, the concentration of choline-containing compounds as well as of alanine turns out to be elevated in the striatum, while the concentration of lactate is elevated in the brainstem. High reproducibility of the method is ensured by the repeated measurement over four months. Relative detectabilities of strongly coupled metabolite resonances at 9.4 T are compared to those at 2.35
dc.contributor.coRefereeDechent, Peter PD Dr.
dc.contributor.thirdRefereePundt, Astrid Prof. Dr.
dc.contributor.thirdRefereeEnderlein, Jörg Prof. Dr.
dc.contributor.thirdRefereeWaack, Stephan Prof. Dr.
dc.contributor.thirdRefereeDamm, Carsten Prof. Dr.
dc.subject.engin vivo NMR spectroscopyde
dc.subject.engmouse brainde
dc.subject.engneurochemical profilede
dc.affiliation.instituteFakultät für Physikde

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