Die Bedeutung von Serum-Antikörpern gegen Myelinproteine vor Erstmanifestation einer Multiplen Sklerose

Franke, Corinna

dc.contributor.advisor	Chan, Andrew Prof. Dr.
dc.contributor.author	Franke, Corinna
dc.date.accessioned	2014-10-22T05:37:10Z
dc.date.available	2014-10-29T23:50:05Z
dc.date.issued	2014-10-22
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-990F-D
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4677
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4677
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4677
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Die Bedeutung von Serum-Antikörpern gegen Myelinproteine vor Erstmanifestation einer Multiplen Sklerose	de
dc.type	doctoralThesis	de
dc.title.translated	The relevance of antimyelin antibodies prior to the first manifestation of multiple sclerosis	de
dc.contributor.referee	Hein, Katharina PD Dr.
dc.date.examination	2014-10-22
dc.description.abstracteng	We investigated the relevance of serum antibodies against the myelin proteins myelin oligodendrocyte glycoprotein and myelin basic protein prior to the first manifestation of multiple sclerosis. Therefor we collected samples of patients, who had donored blood before their diagnosis. IgG and IgM antibodies against linear epitopes were tested by immunoblot. Results: We obtained 58 samples of 25 patients in an interval of 7,3 years to 2 months before the clinically isolated syndrome. Correlations to symptomatology and heaviness of the first event were not found. Also the was no significant differences of antibodystatus between patients and age and gender matched healthy blood donors.	de
dc.contributor.coReferee	Schön, Margarete Prof. Dr.
dc.subject.eng	MOG	de
dc.subject.eng	MBP	de
dc.subject.eng	multiple sclerosis	de
dc.subject.eng	antibodies	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-990F-D-7
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2014-10-29
dc.identifier.ppn	79894207X

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Human- und Zahnmedizin [2872]

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