An Exploration of Real-Time Functional Magnetic Resonance Imaging Neurofeedback in Cognition

Dewiputri, Wan Ilma

dc.contributor.advisor	Frahm, Jens Prof. Dr.
dc.contributor.author	Dewiputri, Wan Ilma
dc.date.accessioned	2014-10-31T10:26:22Z
dc.date.available	2014-10-31T10:26:22Z
dc.date.issued	2014-10-31
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-9924-C
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4752
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	570	de
dc.title	An Exploration of Real-Time Functional Magnetic Resonance Imaging Neurofeedback in Cognition	de
dc.type	doctoralThesis	de
dc.contributor.referee	Frahm, Jens Prof. Dr.
dc.date.examination	2014-10-14
dc.description.abstracteng	This thesis deals with an extensive exploration of the use of rt-fMRI neurofeedback in cognition. Specifically, the work presented here comprises the major steps in the development of a suitable experimental framework for rt-fMRI NF in a cognitive brain region: defining a target region, defining a strategy and protocol for training the target region by NF, and testing the cognitive and behavioral effects of NF training. The target region, the anterior mid-cingulate cortex was defined based on its function in the cognitive process of anticipation, which was probed in the Continuous Performance Task (CPT). Two different methods were compared to analyze fMRI data of the CPT: the classical GLM approach and the combination of ICA with GLM. The next part of this work then details the extensive rt-fMRI neurofeedback training on the aMCC, which had to meet various challenges, which are outlined in detail. To resolve the challenges, this work introduced a novel Serial neurofeedback paradigm, which temporally uncouples self-regulation and feedback appraisal. Compared to the conventional Parallel paradigm, the Serial paradigm emerges as a promising new tool in facilitating learning in rt-fMRI neurofeedback. Finally, this work employed two behavioral tests, the CPT and Flanker task, as measures to investigate the effects of successful self-regulation of the aMCC on the processes of anticipation and conflict resolution, respectively. Overall, the work presented in this thesis is the first extensive rt-fMRI neurofeedback study of the aMCC and provides insights into neurofeedback learning.	de
dc.contributor.coReferee	Treue, Stefan Prof. Dr.
dc.contributor.thirdReferee	Waldmann, Michael Prof. Dr.
dc.contributor.thirdReferee	Dechent, Peter PD Dr.
dc.contributor.thirdReferee	Scherberger, Hansjörg Prof.
dc.subject.eng	fMRI	de
dc.subject.eng	neurofeedback	de
dc.subject.eng	cognition	de
dc.subject.eng	anterior mid-cingulate cortex	de
dc.subject.eng	operant learning	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-9924-C-6
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	799375756

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Das Dokument erscheint in:

GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1112]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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