Gesteigerte hippokampale Neurogenese nach experimenteller bakterieller Meningitis mit Streptococcus pneumoniae

Bering, Judith

dc.contributor.advisor	Gerber, Joachim Prof. Dr.
dc.contributor.author	Bering, Judith
dc.date.accessioned	2014-12-04T09:42:14Z
dc.date.available	2014-12-15T23:50:07Z
dc.date.issued	2014-12-04
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0023-994F-E
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-4809
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.ddc	610	de
dc.title	Gesteigerte hippokampale Neurogenese nach experimenteller bakterieller Meningitis mit Streptococcus pneumoniae	de
dc.type	doctoralThesis	de
dc.title.translated	Increased hippocampal neurogenesis after experimental bacterial meningitis with streptococcus pneumoniae	de
dc.contributor.referee	Gerber, Joachim Prof. Dr.
dc.date.examination	2014-12-08
dc.description.abstracteng	Bacterial meningitis remains a severe disease with high mortality rate. Despite of effective antibiotic therapy a lot of patients suffer from complications and long-term sequelae. The neuronal damage of the hippocampus is a well known attribute in bacterial meningitis – in animal model as well as in humans. The validation of increased neurogenesis after bacterial meningitis in animal model therefore represents an important observation. We investigate the apoptotic and neuroregenerative process in animals with induced bacterial meningitis by Streptococcus pneumoniae. We use two well established animal models – mouse and rabbit. The infected animals were compared with animals in a healty control group. The examined brain area is the dentate gyrus of hippocampus. The number of apoptotic cells is detected by In–Situ–Tailing, the amount of proliferating progenitor cells by BrdU-labeling. To confirm the neuronal origin of the new born cells, some slices are additionally marked by neuronal markers like MAP–2, TUC–4 and beta–tubulin. In both animal models we can show a higher proliferation rate of neuronal progenitor cells after bacterial meningitis, significant in rabbit model (p < 0.05, Mann–Whitney–U–Test). The results can be interpreted as an indication for existing potential for regeneration of central nervous system – especially dentate gyrus of hippocampus. The results of this study may support further research how to optimize influences to neurogenesis, evaluate new therapeutic strategies to reduce neuronal damage and help in better understanding the pathophysiology of bacterial meningitis with its wide range of mechanisms of regulations.	de
dc.contributor.coReferee	Lühder, Fred PD Dr.
dc.subject.ger	Neurogenese	de
dc.subject.ger	Hippokampus	de
dc.subject.ger	Gyrus dentatus	de
dc.subject.ger	bakterielle Meningitis	de
dc.subject.ger	Pneumokokkenmeningitis	de
dc.subject.eng	neurogenesis	de
dc.subject.eng	hippocampus	de
dc.subject.eng	dentate gyrus	de
dc.subject.eng	bacterial meningitis	de
dc.subject.eng	pneumococcal meningitis	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0023-994F-E-5
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.description.embargoed	2014-12-15
dc.identifier.ppn	810687321

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Human- und Zahnmedizin [2872]

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