Analysis of early steps in Assembly of Cytochrome c Oxidase

by Bettina Bareth
Doctoral thesis
Date of Examination:2014-02-26
Date of issue:2014-12-18
Advisor:Prof. Dr. Peter Rehling
Referee:Prof. Dr. Peter Rehling
Referee:Prof. Dr. Stefan Jakobs
Persistent Address: http://dx.doi.org/10.53846/goediss-4834

 

 

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Abstract

English

Cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. Due to its multimeric nature, assembly and maturation requires the concerted action of over 20 assembly factors in yeast. COX is composed of both nuclear- and mitochondria-encoded protein subunits. Its catalytic core is formed by three mitochondria-encoded subunits (Cox1, Cox2 and Cox3) harboring essential prosthetic groups. This study analysed different stages during early cytochrome c oxidase assembly steps and extends the understanding of this process.
Keywords: mitochondria; respiratory chain; COX assembly; Cox1 maturation; heme synthase Cox15
 
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