• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Evaluation der Aktivierung von CD4+ T-Lymphozyten bei Patienten mit Sepsis und akutem Nierenversagen

Time course of CD4+ lymphocyte adenosine triphosphate in sepsis with and without acute kidney injury.

by Maria Brier
Doctoral thesis
Date of Examination:2015-01-14
Date of issue:2014-12-19
Advisor:Prof. Dr. Michael Koziolek
Referee:PD Dr. Daniel Heise
Referee:Prof. Dr. Margarete Schön
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-4806

 

 

Files in this item

Name:dissertation-brier,maria.pdf
Size:909.Kb
Format:PDF
ViewOpen

The following license files are associated with this item:


Abstract

English

A lower CD4+ ATP content even at the time of ICU admission is associated with a worse clinical outcome in patients suffering from sepsis. Moreover, regulatory T cells seem to attenuate nephrotoxic effects in cisplatin nephrotoxicity. The aim of this study was to evaluate CD4+ ATP content in sepsis with or without acute kidney injury (AKI). The immune status of 33 patients with sepsis with and without AKI was prospectively determined on ICU admission as well as 48 and 96 hours thereafter by measuring the CD4+ lymphocyte adenosine triphosphate (ATP) content after mitogen stimulation in whole blood as well as urinary NGAL and correlated with clinical and laboratory data. Eleven septic patients without and 22 with AKI (AKIN 1: n=8, AKIN 2: n=4, AKIN 3: n=10) were included into the study. Time-courses of CD4+ ATP content did not significantly differ between patients with or without AKI (p=0.93) but for urinary NGAL with higher values in AKI (p<0.01; figure 1). Subgroup analysis revealed a significant difference with respect to different AKIN-stadiums (p<0.01; figure 2). Of the AKI-subgroup, 6 patients died and 1 underwent chronic dialysis at discharge. Twelve patients showed partial recovery of renal function  and in 3 patients renal function recovered completely. Time-courses of CD4+ ATP content as well as urinary NGAL in AKI patients tended to differ with respect to renal outcome (p=0.056 and p=0.15, respectively; figure 3 and 4). Time-courses of CD4+ ATP content differ significantly with respect to AKIN stadium in septic patients with a tendency to be a prognostic marker of renal outcome.
Keywords: sepsis; acute kidney injury; CD4+ lymphocyte adenosine triphosphate
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]