Curvotaxis and Pattern Formation in the Actin Cortex of Motile Cells

Blum, Christoph

dc.contributor.advisor	Bodenschatz, Eberhard Prof. Dr.
dc.contributor.author	Blum, Christoph
dc.date.accessioned	2015-12-09T09:40:52Z
dc.date.available	2015-12-09T09:40:52Z
dc.date.issued	2015-12-09
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0028-8667-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5422
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	571.4	de
dc.title	Curvotaxis and Pattern Formation in the Actin Cortex of Motile Cells	de
dc.type	doctoralThesis	de
dc.contributor.referee	Bodenschatz, Eberhard Prof. Dr.
dc.date.examination	2015-09-16
dc.description.abstracteng	Amoeboid cell migration is a crucial part of life. Neutrophil granulocytes, a kind of phagocytes of the mammalian immune system, migrate from blood vessels through tissue towards spots of inflammation. To find this inflammation, they use a chemical “compass” that contains a system to receive and process a chemical signal that guides the neutrophil to the inflammation by leading it towards higher concentration of a chemoattractant molecule. This process is known as chemotaxis, plays also major role is cancer metastasis. The social amoeba Dictyostelium discoideum (D.d.) is a commonly used model organism to study migration as well as chemotaxis. In this study the cell migration of D.d. was investigated within the concept of chemotaxis as well as regarding the geometrical environment of the cells. Here it was found that cells prefere to migrate along paths of high curvature. Hence this finding was called “Curvotaxis”. The open question of a temporal shift between the signalling molecule Ras-G the actin polymerization and the forming of pseudopods was solved by the finding the Ras-G was visible before actin and the propulsion.	de
dc.contributor.coReferee	Enderlein, Jörg Prof. Dr.
dc.subject.eng	Curvotaxis	de
dc.subject.eng	Cell migration	de
dc.subject.eng	Chemotaxis	de
dc.subject.eng	Ras	de
dc.subject.eng	Dictyostelium	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0028-8667-5-9
dc.affiliation.institute	Göttinger Graduiertenschule für Neurowissenschaften, Biophysik und molekulare Biowissenschaften (GGNB)	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	843242450

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GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften [1112]
GGNB - Göttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences

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