Intraorale Druckmessungen bei dysphagischen ALS-Patienten im Vergleich zu einem Normkollektiv

Böning, Deike Dr. Dr.

dc.contributor.advisor	Olthoff, Arno PD Dr.
dc.contributor.author	Böning, Deike Dr. Dr.
dc.date.accessioned	2016-01-18T10:42:58Z
dc.date.available	2016-02-10T23:50:09Z
dc.date.issued	2016-01-18
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0028-8694-E
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5463
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Intraorale Druckmessungen bei dysphagischen ALS-Patienten im Vergleich zu einem Normkollektiv	de
dc.type	doctoralThesis	de
dc.title.translated	Intra-oral maximal suction pressure indicates dysphagia in patients with amyotrophic lateral sclerosis	de
dc.contributor.referee	Engelke, Wilfried Prof. Dr. Dr.
dc.date.examination	2016-02-03
dc.description.abstracteng	Apart from mechanical positive pressures (e.g. maximal tongue strength) negative atmospheric pressure gradients are given as intra-oral forces. Up to date clinical relevance of these forces is still indistinct. The aim of the present study is to give an insight into the intra-oral atmospheric maximal pressure of a reference group in contrast to dysphagic patients with amyotrophic lateral sclerosis (ALS). Therefore 20 healthy volunteers and 10 patients suffering from ALS underwent a flexible endoscopic evaluation of swallowing (FEES), a manometric measurement of the maximal intra-oral atmospheric pressure generated by suction as well as of the prevalent pressure during swallowing. Additionally the sydney swallowing questionnaire (SSQ) was completed by all participants to score the self-rated extent of dysphagia. All participants presented negative intra-oral pressure during swallowing and no significant difference was seen between ALS patients and healthy volunteers. Regarding maximal suction the comparison of both groups showed significant lower maximal atmospheric pressures in ALS patients (p<0.001). Subtracting the negative intra-oral pressure during swallowing the maximal negative pressure seems to represent a “functional reserve” that ensures normal swallowing. Significant correlations of maximal pressure and “functional reserve” versus SSQ-score were seen (r1=-0.73; r2=-0.65). As the oral cavity is an easy accessible compartment of the upper digestive tract, future manometric measurement could be proved as technique for screening, diagnostic and therapeutic control or biofeedback in ALS and other dysphagic patients.	de
dc.contributor.coReferee	Schön, Margarete Prof. Dr.
dc.subject.ger	intraoraler Sog	de
dc.subject.ger	Schluckvorgang	de
dc.subject.ger	Dysphagie	de
dc.subject.ger	funktionelle Reserve	de
dc.subject.ger	Manometrie	de
dc.subject.ger	Saugvorgang	de
dc.subject.ger	amyotrophe Lateralsklerose	de
dc.subject.eng	intra-oral pressure	de
dc.subject.eng	swallowing	de
dc.subject.eng	dysphagia	de
dc.subject.eng	functional reserve	de
dc.subject.eng	manometry	de
dc.subject.eng	suction	de
dc.subject.eng	amyotrophic lateral sclerosis	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0028-8694-E-6
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Zahn-, Mund- und Kieferheilkunde - Allgemein- und Gesamtdarstellungen (PPN619876360)	de
dc.subject.gokfull	Neurologie - Allgemein- und Gesamtdarstellungen (PPN619876247)	de
dc.subject.gokfull	Oto-Rhino-Laryngologie (PPN619876220)	de
dc.description.embargoed	2016-02-10
dc.identifier.ppn	846018802

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