Histopathologische Veränderungen im zentralen Nervensystem nach peripherer Stammzelltransplantation

Histopathologische Veränderungen im zentralen Nervensystem nach peripherer Stammzelltransplantation

Histopathological changes found in the central nervous system after peripheral blood stem cell transplantation

Knust, Elisabeth

Dissertation

Angenommen am: 2016-03-03

Erschienen: 2016-03-04

Betreuer: Metz, Imke PD Dr.

Gutachter: Wulf, Gerald Prof. Dr.

Gutachter: Meyer, Thomas Prof. Dr.

Zum Verlinken/Zitieren: http://hdl.handle.net/11858/00-1735-0000-0028-86EC-A

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Zusammenfassung

Englisch

Peripheral blood stem cell transplantation is used as a treatment for different hemic diseases and some autoimmune disorders. We examined histopathological changes in the central nervous system of 19 patients who underwent autopsy studies following peripheral blood stem cell transplantation. The histological features of patients having received a stem cell transplantation were compared to patients who had not received any such treatment. Significant differences were found concerning the oligodendrocytes and oligodendrocyte precursors in the subventricular zone. Nevertheless, evidence of substantial damage caused by peripheral blood stem cell transplantation could not be provided. In the second part of our study, combining in-situ-hybridization and immunohistochemical methods, we were able to show that there is a migration of donor cells into the central nervous system of the recipient after peripheral blood stem cell transplantation as well as a differentiation of these cells into other cell types. These results indicate that further investigation is needed to analyse risk and benefit of peripheral blood stem cell transplantation used for new therapeutic indications.

Keywords: peripheral blood stem cell transplantation; chemotherapy; radiation; central nervous system; histopathological changes; autologous stem cell transplantation; allogeneic stem cell transplantation

Schlagwörter: periphere Blutstammzelltransplantation; Chemotherapie; Bestrahlung; ZNS; autologe Transplantation; allogene Transplantation; Histopathologie