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Histopathologische Veränderungen im zentralen Nervensystem nach peripherer Stammzelltransplantation

dc.contributor.advisorMetz, Imke PD Dr.
dc.contributor.authorKnust, Elisabeth
dc.date.accessioned2016-03-04T07:34:20Z
dc.date.available2016-03-10T23:50:05Z
dc.date.issued2016-03-04
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-0028-86EC-A
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5534
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleHistopathologische Veränderungen im zentralen Nervensystem nach peripherer Stammzelltransplantationde
dc.typedoctoralThesisde
dc.title.translatedHistopathological changes found in the central nervous system after peripheral blood stem cell transplantationde
dc.contributor.refereeWulf, Gerald Prof. Dr.
dc.date.examination2016-03-03
dc.description.abstractengPeripheral blood stem cell transplantation is used as a treatment for different hemic diseases and some autoimmune disorders. We examined histopathological changes in the central nervous system of 19 patients who underwent autopsy studies following peripheral blood stem cell transplantation. The histological features of patients having received a stem cell transplantation were compared to patients who had not received any such treatment. Significant differences were found concerning the oligodendrocytes and oligodendrocyte precursors in the subventricular zone. Nevertheless, evidence of substantial damage caused by peripheral blood stem cell transplantation could not be provided. In the second part of our study, combining in-situ-hybridization and immunohistochemical methods, we were able to show that there is a migration of donor cells into the central nervous system of the recipient after peripheral blood stem cell transplantation as well as a differentiation of these cells into other cell types.  These results indicate that further investigation is needed to analyse risk and benefit of peripheral blood stem cell transplantation used for new therapeutic indications.de
dc.contributor.coRefereeMeyer, Thomas Prof. Dr.
dc.subject.gerperiphere Blutstammzelltransplantationde
dc.subject.gerChemotherapiede
dc.subject.gerBestrahlungde
dc.subject.gerZNSde
dc.subject.gerautologe Transplantationde
dc.subject.gerallogene Transplantationde
dc.subject.gerHistopathologiede
dc.subject.engperipheral blood stem cell transplantationde
dc.subject.engchemotherapyde
dc.subject.engradiationde
dc.subject.engcentral nervous systemde
dc.subject.enghistopathological changesde
dc.subject.engautologous stem cell transplantationde
dc.subject.engallogeneic stem cell transplantationde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-0028-86EC-A-9
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullPathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674)de
dc.description.embargoed2016-03-10
dc.identifier.ppn849288320


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