Histopathologische Veränderungen im zentralen Nervensystem nach peripherer Stammzelltransplantation

Knust, Elisabeth

dc.contributor.advisor	Metz, Imke PD Dr.
dc.contributor.author	Knust, Elisabeth
dc.date.accessioned	2016-03-04T07:34:20Z
dc.date.available	2016-03-10T23:50:05Z
dc.date.issued	2016-03-04
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0028-86EC-A
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5534
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Histopathologische Veränderungen im zentralen Nervensystem nach peripherer Stammzelltransplantation	de
dc.type	doctoralThesis	de
dc.title.translated	Histopathological changes found in the central nervous system after peripheral blood stem cell transplantation	de
dc.contributor.referee	Wulf, Gerald Prof. Dr.
dc.date.examination	2016-03-03
dc.description.abstracteng	Peripheral blood stem cell transplantation is used as a treatment for different hemic diseases and some autoimmune disorders. We examined histopathological changes in the central nervous system of 19 patients who underwent autopsy studies following peripheral blood stem cell transplantation. The histological features of patients having received a stem cell transplantation were compared to patients who had not received any such treatment. Significant differences were found concerning the oligodendrocytes and oligodendrocyte precursors in the subventricular zone. Nevertheless, evidence of substantial damage caused by peripheral blood stem cell transplantation could not be provided. In the second part of our study, combining in-situ-hybridization and immunohistochemical methods, we were able to show that there is a migration of donor cells into the central nervous system of the recipient after peripheral blood stem cell transplantation as well as a differentiation of these cells into other cell types. These results indicate that further investigation is needed to analyse risk and benefit of peripheral blood stem cell transplantation used for new therapeutic indications.	de
dc.contributor.coReferee	Meyer, Thomas Prof. Dr.
dc.subject.ger	periphere Blutstammzelltransplantation	de
dc.subject.ger	Chemotherapie	de
dc.subject.ger	Bestrahlung	de
dc.subject.ger	ZNS	de
dc.subject.ger	autologe Transplantation	de
dc.subject.ger	allogene Transplantation	de
dc.subject.ger	Histopathologie	de
dc.subject.eng	peripheral blood stem cell transplantation	de
dc.subject.eng	chemotherapy	de
dc.subject.eng	radiation	de
dc.subject.eng	central nervous system	de
dc.subject.eng	histopathological changes	de
dc.subject.eng	autologous stem cell transplantation	de
dc.subject.eng	allogeneic stem cell transplantation	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0028-86EC-A-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Pathologie / Pathologische Anatomie / Histopathologie / Zytopathologie - Allgemein- und Gesamtdarstellungen (PPN619875674)	de
dc.description.embargoed	2016-03-10
dc.identifier.ppn	849288320

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Human- und Zahnmedizin [2872]

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