Die Wirkung von Genistein und Equol in Kombination mit Vibrationstraining auf Knochenparameter der orchidektomierten Ratte während einer Knochendefektheilung

Henze, Sara

dc.contributor.advisor	Seidlová-Wuttke, Dana PD Dr.
dc.contributor.author	Henze, Sara
dc.date.accessioned	2016-03-04T10:21:45Z
dc.date.available	2016-03-23T23:50:05Z
dc.date.issued	2016-03-04
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0028-86EE-6
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5524
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Die Wirkung von Genistein und Equol in Kombination mit Vibrationstraining auf Knochenparameter der orchidektomierten Ratte während einer Knochendefektheilung	de
dc.type	doctoralThesis	de
dc.title.translated	The effect of Genistein and Equol combined with vibration therapy on bone parameters during the bone healing of an orchiectomized rat	de
dc.contributor.referee	Wuttke, Wolfgang Prof. Dr.
dc.date.examination	2016-03-16
dc.description.abstracteng	Not only women but also men suffer from Osteoporosis. Pathophysiologically the disease is characterized by a decreasing bone density which initially affects the cancellous bone, later on the cortical. In our first part of the trial 172 male Sprague- Dawley rats were vibrated five days/ week for 15 min at 25-30 Hz for four weeks, immediately after Orchiectomy. We were able to confirm, as measured by peripheral quantitative computed tomography the preservation of the cancellous bone through preventive vibration therapy. In our second part we examined the effect of a two, three or eight week administration of Genistein and Equol. The control group received soy -free feed. The substitution of genistein and equol could tend to slow the continuous decrease of the BMD (bone mineral density) of the cancellous bone. The osteoporotic bone often suffers a fracture. We wanted to study the effect of the phytohormones during a bone defect healing. We therefore triggered an experimental bone defect by trepanation of the cortical tibia. Genistein and equol were applied for two, three or eight weeks. Genistein could accelerate the mineralization of the cortical bone while the bone healing. A further aim of the study was to examine the combination of phytohormones and vibration therapy while the healing process. A few animals were vibrated again six weeks after the bone defect. The combination of Genistein and vibration seems stabilizes the bone the most. Finally we examined the the cross-sectional area of the muscle paratibial and its fat depot. The results were not very meaningful, so another analytical method for muscle mass and strength may be useful.	de
dc.contributor.coReferee	Wiese, Karl Günter Prof. Dr. Dr.
dc.subject.ger	Osteoporose beim Mann	de
dc.subject.ger	Phytohormone	de
dc.subject.ger	Genistein	de
dc.subject.ger	Equol	de
dc.subject.ger	Knochendefektheilung	de
dc.subject.ger	Trepanation	de
dc.subject.ger	Ganzkörpervibration	de
dc.subject.eng	Osteoporosis	de
dc.subject.eng	Phytohormones	de
dc.subject.eng	Whole body vibration	de
dc.subject.eng	fracture healing	de
dc.subject.eng	Genistein	de
dc.subject.eng	Equol	de
dc.subject.eng	Trepanation	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0028-86EE-6-8
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.subject.gokfull	Chirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968)	de
dc.subject.gokfull	Geriatrie / Gerontologie / Altenpflege - Allgemein- und Gesamtdarstellungen (PPN61987662X)	de
dc.subject.gokfull	Orthopädie (PPN619876204)	de
dc.description.embargoed	2016-03-23
dc.identifier.ppn	849288363

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Human- und Zahnmedizin [2872]

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