Parakrine Beeinflussung der Genexpression in vitro von chondrogenen Zellen in der Osteoarthrose

Paracrine modulation of the gene-expression in vitro of chondrogenic cells in osteoarthritis

by Phillip Marks
Doctoral thesis
Date of Examination:2016-03-23
Date of issue:2016-03-22
Advisor:Prof. Dr. Nicolai Miosge
Referee:Prof. Dr. Rüdiger Behr
Referee:Prof. Dr. Margarete Schön
Persistent Address: http://dx.doi.org/10.53846/goediss-5578

 

 

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Abstract

English

Analysis of the gene-Expression profiles of mesenchymal stem cells (MSC), chondrogenic progenitor cells (CPC) and Chondrocytes in 3D-Coculture-Systems and in conditions with osteoarthrotic conditioned culture media. The results show CPC in similar potential of paracrine Mediation as MSC. Further we could prove indifferent trophic mediation of osteoarthritic cartilage independently from the grade of degradation.
Keywords: mesenchymal stem cells; chondrogenic progenitor cells; cartilage; paracrine; gene expression
Schlagwörter: Osteoarthrose; Mesenchymale Stammzellen; Chondrogene Progenitorzellen; Genexpression; parakrin; Gelenkknorpel
 
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