Parakrine Beeinflussung der Genexpression in vitro von chondrogenen Zellen in der Osteoarthrose

Paracrine modulation of the gene-expression in vitro of chondrogenic cells in osteoarthritis

von Phillip Marks
Dissertation
Datum der mündl. Prüfung:2016-03-23
Erschienen:2016-03-22
Betreuer:Prof. Dr. Nicolai Miosge
Gutachter:Prof. Dr. Rüdiger Behr
Gutachter:Prof. Dr. Margarete Schön
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-5578

 

 

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Zusammenfassung

Englisch

Analysis of the gene-Expression profiles of mesenchymal stem cells (MSC), chondrogenic progenitor cells (CPC) and Chondrocytes in 3D-Coculture-Systems and in conditions with osteoarthrotic conditioned culture media. The results show CPC in similar potential of paracrine Mediation as MSC. Further we could prove indifferent trophic mediation of osteoarthritic cartilage independently from the grade of degradation.
Keywords: mesenchymal stem cells; chondrogenic progenitor cells; cartilage; paracrine; gene expression
Schlagwörter: Osteoarthrose; Mesenchymale Stammzellen; Chondrogene Progenitorzellen; Genexpression; parakrin; Gelenkknorpel
 
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