Therapeutisches Potenzial und Langzeiteffekt der TLR4-Inhibition bei der fokalen zerebralen Ischämie

Andresen, Lena

dc.contributor.advisor	Trendelenburg, George Prof. Dr.
dc.contributor.author	Andresen, Lena
dc.date.accessioned	2016-04-11T11:08:07Z
dc.date.available	2018-02-13T23:50:46Z
dc.date.issued	2016-04-11
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-0028-872B-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5608
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Therapeutisches Potenzial und Langzeiteffekt der TLR4-Inhibition bei der fokalen zerebralen Ischämie	de
dc.type	doctoralThesis	de
dc.title.translated	Therapeutic potential and long term effect of TLR4 inhibition in focal cerebral ischemia	de
dc.contributor.referee	Trendelenburg, George Prof. Dr.
dc.date.examination	2016-05-11
dc.description.abstracteng	Ischemic stroke is known to be one of the leading causes of death worldwide. As therapeutic options especially for treatment beyond 4,5 to 6 hours after the beginning of symptoms are limited, recent studies have focussed on the therapeutic protection of the penumbra, where the brain tissue is damaged by post-ischemic process. In this doctoral thesis the effect of antibody-induced inhibition of the toll-like receptor 4 (TLR4), a receptor being involved in the post-ischemic immune response, has been investigated in a murine model of cerebral ischemia. Since neuroprotective effects of TLR4 inhibition have already been shown in recent studies after 48 hours of post-ischemic reperfusion, this work concentrates on the effect of TLR4 inhibition 14 days after mild cerebral ischemia (15 minutes of middle cerebral artery occlusion). The anti-TLR4/MD2-antibody MTS510 or PBS has been applied intraarterially shortly before MCAO. Analysis was based on neurological tests, infarct volumes as well as cell quantification based on immunohistochemical staining. Neither of these parameters showed any significant difference among the mice that received the antibody and those being part of the control group. As comparable long term studies with transgene mouse models did show neuroprotective effects of TLR4 inhibition and a high mortality occurred in both groups despite modifications of the experimental set-up, further studies are needed before clinical investigation.	de
dc.contributor.coReferee	Bayer, Thomas A. Prof. Dr.
dc.subject.ger	Schlaganfall	de
dc.subject.ger	fokale zerebrale Ischämie	de
dc.subject.ger	experimenteller Schlaganfall	de
dc.subject.ger	MCAO	de
dc.subject.ger	TLR4	de
dc.subject.ger	Neuroprotektion	de
dc.subject.eng	stroke	de
dc.subject.eng	experimental stroke	de
dc.subject.eng	focal cerebral ischemia	de
dc.subject.eng	MCAO	de
dc.subject.eng	TLR4	de
dc.subject.eng	neuroprotection	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-0028-872B-5-9
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2018-02-13
dc.identifier.ppn	856624519

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