| dc.contributor.advisor | Mihm, Sabine Prof. Dr. | |
| dc.contributor.author | Gerber, Sebastian | |
| dc.date.accessioned | 2016-06-20T06:32:56Z | |
| dc.date.available | 2016-07-07T22:50:05Z | |
| dc.date.issued | 2016-06-20 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0028-878B-B | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5678 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Assoziation des PDCD1 rs11568821 GG-Genotyps mit stärkerer Morbidität bei Intensivpatienten mit Krankheitsbild Sepsis: Vergleich der SOFA-Sub-Scores | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Association of the PDCD1 rs11568821 GG-genotype with higher morbidity of patients with sepsis at ICU: Comparison of the SOFA-sub-scores | de |
| dc.contributor.referee | Mihm, Sabine Prof. Dr. | |
| dc.date.examination | 2016-06-30 | |
| dc.description.abstracteng | The failing of various therapeutic agents in the treatment of sepsis elucidates the still existing lack of knowledge of this syndrome. Over the last years a major change has taken place as results have shown that, beside a cytokine-storm in an early hyper-inflammatory state, negative co-stimulatory receptors along with a late hypo-inflammatory state play a crucial role in the complex pathophysiology of sepsis. One of these receptors is PD-1, which is encoded by the gene PDCD1. The aim of this study was to illustrate whether a genetic predisposition (PDCD1 rs11568821 GG-genotype), which causes a higher expression of PD-1, accompanies a higher dysfunction of certain organ systems in septic patients.
Therefore the PDCD1 rs11568821-genotype and relevant daily parameters as for example the sequential organ failure assessment (SOFA)-score of 300 ICU-patients were examined. Possible confounding variables were excluded.
For the first time the results of this study show associations of the PDCD1 rs11568821 GG-genotype with a higher morbidity of CNS, respiration, cardiovascular system and liver present in septic patients. This is expressed by significant higher mean SOFA-sub-scores of respiration, cardiovascular system and CNS for the disease´s process and by prolonged higher mean sub-scores of CNS and cardiovascular system. Additionally none of the A-allele carriers show an acute liver failure in the first days of the disease´s process. Analysises of mortality indicate associations of PDCD1 rs11568821 GG-genotype with a lower survival rate.
Consequently associations of a genetic variation in the negative co-stimulatory receptor PD-1´s gene with higher morbidity of chosen organ systems can be perceived. After a validation of these results through an independent collective, the SNP PDCD1 rs11568821 may become a prognostic and predictive factor related to a therapy of sepsis-associated organ dysfunctions while using anti-PD-1-antibodies in the context of advancing personalized medicine. | de |
| dc.contributor.coReferee | Bickeböller, Heike Prof. Dr. | |
| dc.subject.ger | Sepsis | de |
| dc.subject.ger | PD-1 | de |
| dc.subject.ger | PDCD1 rs11568821 | de |
| dc.subject.ger | Morbidität | de |
| dc.subject.ger | Intensivstation | de |
| dc.subject.ger | SOFA-Score | de |
| dc.subject.ger | GG-Genotyp | de |
| dc.subject.ger | Herz-Kreislauf-System | de |
| dc.subject.ger | Atmung | de |
| dc.subject.ger | ZNS | de |
| dc.subject.eng | Sepsis | de |
| dc.subject.eng | PD-1 | de |
| dc.subject.eng | PDCD1 rs11568821 | de |
| dc.subject.eng | morbidity | de |
| dc.subject.eng | ICU | de |
| dc.subject.eng | SOFA-Score | de |
| dc.subject.eng | GG-genotype | de |
| dc.subject.eng | cardiovascular system | de |
| dc.subject.eng | respiration | de |
| dc.subject.eng | CNS | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0028-878B-B-6 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.description.embargoed | 2016-07-07 | |
| dc.identifier.ppn | 861659074 | |