| dc.contributor.advisor | Zabel, Markus Prof. Dr. | |
| dc.contributor.author | Wessels, Ansgar Wilhelm | |
| dc.date.accessioned | 2016-06-21T08:54:51Z | |
| dc.date.available | 2016-07-13T22:50:08Z | |
| dc.date.issued | 2016-06-21 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-0028-8790-E | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5690 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5690 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5690 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Vorhersagbarkeit von klinischen Ereignissen bei Patienten mit einem implantierbaren Kardioverter-Defibrillator durch Auswertungen aus dem 24-Stunden-Langzeit-EKG | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Predictability of clinical events in patients with implantable cardioverter-defibrillator through analysis of 24h-long-term ECG recordings | de |
| dc.contributor.referee | Meyer, Thomas Prof. Dr. | |
| dc.date.examination | 2016-07-06 | |
| dc.description.abstracteng | Sudden cardiac death caused by sustained ventricular arrhythmia is the most common cause of death in western industrial nations. The implantation of an implantable cardioverter defibrillator (ICD) is a treatment, which can quit life-threatening arrhythmias effectively. Methods of determining individual risk of life-threatening arrhythmias need to be improved as currently some patients receive ICDs who will never profit from this device.
This single-center observational study examined in 150 patients, who according to current indications an ICD was implanted, the prognostic value of common 24h-long-term-ECG risk markers such as ventricular ectopia, heart rate variability, heart rate turbulence, deceleration- and aceleration capacity on clinical outcome. A selection of patients for a particular cardiac condition was not performed.
Mean follow-up was 28 ± 12 months. During this period 25 patients died and 20 patients received an appropriate ICD shock. None of the investigated 24h-long-term-ECG risk markers showed a statistically significantly increased risk of achieving the endpoints all cause mortality or occurrence of appropiate ICD shocks regardless of age and sex. Regardless of age and sex the 24h-long-term-ECG risk markers ventricular extrasystoles, nsVT and HRT 1 showed a statistical trend for an increased risk for receiving appropiate ICD shocks. Only the risk marker nsVT showed in multivariate analysis a statistically significantly increased risk for the achievement of a combined end point of all-cause mortality and occurrence of appropiate ICD shocks (HR: 1.91 95% CI: 1.01 to 3.61, p value: 0,05).
The size of the examined registry allows only a limited calculation of the predictive value of 24h-long-term-ECG risk markers. Further investigations of the prognostic relevance of 24h-long-term-ECG risk markers for patients with ICD should be realized in larger clinical trials. | de |
| dc.contributor.coReferee | Sigler, Matthias Prof. Dr. | |
| dc.contributor.thirdReferee | Schön, Margarete Prof. Dr. | |
| dc.subject.eng | Sudden cardiac death | de |
| dc.subject.eng | implantable cardioverter defibrillator | de |
| dc.subject.eng | 24h-long-term-ECG | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-0028-8790-E-4 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Medizin (PPN619874732) | de |
| dc.subject.gokfull | Kardiologie (PPN619875755) | de |
| dc.description.embargoed | 2016-07-13 | |
| dc.identifier.ppn | 861741595 | |