Charakterisierung von Prädiktoren rapid-progressiver Verläufe des M. Alzheimer

Characterization of predictors for rapid progressive cognitive decline in Alzheimer´s Disease

by Thomas Bartlau
Doctoral thesis
Date of Examination:2016-07-12
Date of issue:2016-07-12
Advisor:Prof. Dr. Inga Zerr
Referee:Prof. Dr. Inga Zerr
Referee:Prof. Dr. Reinhard Hilgers
Persistent Address: http://dx.doi.org/10.53846/goediss-5745

 

 

Files in this item

Name:Dissertation_Juli_2016-5.pdf
Size:1.76Mb
Format:PDF

The following license files are associated with this item:

Abstract

English

Alzheimer´s Disease (AD) is a neurodegenerative disorder, whose causes still have to be elucidated. The courses of the disease are heterogen, and rapid progresses were discribed. The data about risk factors and predictors of rapid progressive AD is still unclear. Cellular Prion Protein (PrPc) is a cell surface protein, especially of the neural tissue. Interactions of PrPc with the neuropathological hallmarks of AD, like Aß and its precursor proteins, as well as Tau, pTau and their metabolic pathways has been discribed recently. In a longitudal, prospective study we researched if PrPc in cerebrospinal fluid (CSF) of subjects with probable AD as well as other csf-biomarkers are suitable as predictors of rapid progressive cognitive decline in AD. We could show among others, that CSF-PrPc highly correlates negativly with cognitive decline in female subjects with APOE ε3/3 genotype and suggest, that PrPc in CSF could be a predictor of rpAD in specific cases.
Keywords: Alzheimer´s Disease; rpAD; Prion Protein
 
Statistik