• Deutsch
    • English
  • English 
    • Deutsch
    • English
  • Login
Item View 
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
  •   Home
  • Medizin
  • Human- und Zahnmedizin
  • Item View
JavaScript is disabled for your browser. Some features of this site may not work without it.

Analyse von Interleukin-10-Genvariationen bei diffus großzelligen B-Zell-Lymphomen

Analysis of Interleukin-10 gene variations in diffuse large B-cell lymphoma

by Julia Stächele
Doctoral thesis
Date of Examination:2016-09-22
Date of issue:2016-09-12
Advisor:Prof. Dr. Dieter Kube
Referee:Prof. Dr. Dieter Kube
Referee:Prof. Dr. Tim Beißbarth
crossref-logoPersistent Address: http://dx.doi.org/10.53846/goediss-5850

 

 

Files in this item

Name:Dissertation Julia Staechele.pdf
Size:921.Kb
Format:PDF
ViewOpen

The following license files are associated with this item:


Abstract

English

Although Non-Hodgkin lymphoma principally can be cured due to current therapy strategies some patients do not achieve complete remission. Besides many patients are affected by significant therapy-related toxicities. In searching for new clinically relevant and applicable prognostic markers gene variations in cytokines are increasingly taken into consideration since they may be involved in the development and clinical course of lymphomas. Therefore we analyzed three distal single nucleotide polymorphisms (IL-10-12.806TC, IL-10-11.777GA und IL-10-11.668GA) as well as one gene variation of the 3’UTR of the Interleukin-10 (IL-10) gene (IL-10+4.259AG) in 594 patients with diffuse large B-cell lymphoma (DLBCL). Furthermore the IL-10 gene expression has been studied since particular IL-10 gene variations may be associated with distinct IL-10 expression. Within genotyping analyses the already established SNaPshot analysis could be successfully extended to a multiplex assay. Apart from univariate analyses of the gene variations we also performed multivariate analyses adjusted to IPI factos. Hereby no significant differences concerning overall survival and event-free survival could be found. Nevertheless DLBCL patients carrying genotype AA of the gene variation IL-10-11.777GA tend to show better event-free survival in contrast to heterozygote carriers. In addition, genotype AA of the gene variation IL-10+4.259AG may be associated with the development of a DLBCL since this genotype was significantly more frequent among patients compared with healthy controls.  Since there was only partially evidence for interindividual differences in IL-10 gene expression further studies should be conducted.
Keywords: Interleukin-10; gene variations; diffuse large B-cell lymphoma
 

Statistik

Publish here

Browse

All of eDissFaculties & ProgramsIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesTypeThis FacultyIssue DateAuthorAdvisor & RefereeAdvisorRefereeTitlesType

Help & Info

Publishing on eDissPDF GuideTerms of ContractFAQ

Contact Us | Impressum | Cookie Consents | Data Protection Information | Accessibility
eDiss Office - SUB Göttingen (Central Library)
Platz der Göttinger Sieben 1
Mo - Fr 10:00 – 12:00 h


Tel.: +49 (0)551 39-27809 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
ediss_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]
Göttingen State and University Library | Göttingen University
Medicine Library (Doctoral candidates of medicine only)
Robert-Koch-Str. 40
Mon – Fri 8:00 – 24:00 h
Sat - Sun 8:00 – 22:00 h
Holidays 10:00 – 20:00 h
Tel.: +49 551 39-8395 (general inquiries)
Tel.: +49 (0)551 39-28655 (open access/parallel publications)
bbmed_AT_sub.uni-goettingen.de
[Please replace "_AT_" with the "@" sign when using our email adresses.]