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dc.contributor.advisor Thoms, Sven PD Dr.
dc.contributor.author Frick, Jessica
dc.date.accessioned 2016-09-19T08:27:13Z
dc.date.available 2017-09-19T22:50:04Z
dc.date.issued 2016-09-19
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7BFF-2
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Peroxisomale Biogenese - Beteiligung Dynamin-ähnlicher Proteine und die Rolle des endoplasmatischen Retikulums de
dc.type doctoralThesis de
dc.title.translated Peroxisomal biogenesis - the participation of dynamin-related proteins and the role fo the endoplasmatic reticulum de
dc.contributor.referee Thoms, Sven PD Dr.
dc.date.examination 2016-09-19
dc.description.abstracteng This present work deals with the peroxisomal biogenesis and should help to understand it. The work focuses on the participation of the dynamin-like protein Vps1p in the process of the peroxisomal biogenesis in S. cerevisiae. It is already published that Vps1p is important for division of preperoxisomal structures into individual peroxisomes. The results of the experiment showed that Vps1p has another function in peroxisomal biogenesis; this function is ER dependent and happens already at an early state of peroxisomal neogenesis. Since a connection between peroxisomes and ER has been observed before, another part of this work deals with the local and functional connection of peroxisomes and ER. To investigate this, there are shown live-cell experiments and also a protocol for immunofluorescence microscopy has been established. Both experiments showed clearly the connection between the two organelles. Because of that a lifetime commitment between peroxisomes and ER is most likely. Another aspect dealt with the question whether peroxisomes in wild-type cells - as currently postulated in the literature - arise only by the way of growth and division or via de novo formation. The results of this study indicate that in wild-type cells de novo formation of peroxisomes takes place. It is possible that both systems run in parallel in wild-type cells. de
dc.contributor.coReferee Kehlenbach, Ralph Prof. Dr.
dc.subject.ger Peroxisomale Biogenese de
dc.subject.ger Dynamin-ähnliche Proteine de
dc.subject.eng peroxisomal biogenesis de
dc.subject.eng Dynamin-related proteins de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7BFF-2-0
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.description.embargoed 2017-09-19
dc.identifier.ppn 869251074

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