Ruthenium(II)-Catalyzed C-H Arylations of Arenes

von Jonathan Hubrich
Dissertation
Datum der mündl. Prüfung:2016-09-30
Erschienen:2016-10-10
Betreuer:Prof. Dr. Lutz Ackermann
Gutachter:Prof. Dr. Lutz Ackermann
Gutachter:Dr. Alexander Breder
Zum Verlinken/Zitieren: http://dx.doi.org/10.53846/goediss-5885

 

 

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Zusammenfassung

Englisch

The goal of this work was to devise environmentally friendly and cost-effective novel concepts for the efficient synthesis of biaryl units as core structure in biologically active compounds, which are of great importance to the agrochemical and pharmaceutical industries. Transition metal-catalyzed direct functionalization processes of otherwise inert C‒H bonds emerged as a more sustainable alternative to the classically used cross-coupling reactions for the synthesis of biaryls. For this reason, the research was focused on the development of novel methods for efficient and selective direct C‒H transformations to construct biaryl scaffolds in an atom- and step-economical manner.
Keywords: ruthenium; arylation; C-H activation; bioactive compounds; biaryl
 
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