Untersuchungen zur enantioselektiven Totalsynthese von Parnafungin C
Studies towards the Enantioselective Total Synthesis of Parnafungin C
von Sven Heidemann
Datum der mündl. Prüfung:2016-08-04
Erschienen:2016-10-10
Betreuer:Prof. Dr. Dr. h.c. Lutz Tietze
Gutachter:Prof. Dr. Dr. H.c. Lutz Tietze
Gutachter:Prof. Dr. Ulf Diederichsen
Dateien
Name:dissertation_heidemann_sven.pdf
Size:6.30Mb
Format:PDF
Zusammenfassung
Englisch
Within this thesis, two fragments of the natural product Parnafungin C, a highly functionalized chiral chromane with the correct absolute and relative configuration of all stereogenic centers as well as a biaryl system comprising all required substituents for the formation of the unique isoxazolidinone-moiety, were synthesized. Key steps are an enantioselective Wacker oxidation or a Domino-Wacker/carbonylation/methoxylation reaction, a Sharpless asymmetric dihydroxylation reaction and a Suzuki-Miyaura cross coupling reaction.
Keywords: Parnafungin C; Enantioselective Total Synthesis; Wacker oxidation; Domino reaction; Suzuki-Miyaura cross coupling; Sharpless dihydroxylation