HECT-type Ubiquitin Ligases in Nerve Cell Development

Ambrozkiewicz, Mateusz Cyryl

dc.contributor.advisor	Brose, Nils Prof. Dr.
dc.contributor.author	Ambrozkiewicz, Mateusz Cyryl
dc.date.accessioned	2016-10-11T08:08:42Z
dc.date.available	2016-10-11T08:08:42Z
dc.date.issued	2016-10-11
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002B-7C1D-5
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5884
dc.language.iso	eng	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	570	de
dc.title	HECT-type Ubiquitin Ligases in Nerve Cell Development	de
dc.type	doctoralThesis	de
dc.contributor.referee	Stegmüller, Judith Dr.
dc.date.examination	2015-11-19
dc.description.abstracteng	Development of neurons begins in the middle of embryogenesis after closure of the neural tube. In the process of neurogenesis, neural stem cells generate nerve cells by asymmetric cell divisions at the ventricular zone of the brain. Immature neurons embark for their destination and start projecting axons and dendrites during migration. Growing axons are guided across the embryo towards their target neurons, and upon synaptogenesis and synapse elimination create complex architecture of the neural networks. Emerging evidence unveils that posttranslational modification by protein ubiquitylation and posttranscriptional regulation of gene expression by microRNAs are of particular importance for the nerve cell development. In this study, we demonstrate the roles of HECT-type ubiquitin ligases in newborn and mature nerve cells. Additionally, we characterize intronic microRNA and its host gene encoding for HECT-type ubiquitin ligase in developing nerve cells. Our work provides novel molecular insights for nerve cell development and contributes to present understanding of molecular cellular pathologies in intellectual disability syndrome.	de
dc.contributor.coReferee	Mansouri, Ahmed Prof. Dr.
dc.subject.eng	Ubiquitin	de
dc.subject.eng	Development	de
dc.subject.eng	HECT	de
dc.subject.eng	Neuronal Migration	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C1D-5-3
dc.affiliation.institute	Biologische Fakultät für Biologie und Psychologie	de
dc.subject.gokfull	Biologie (PPN619462639)	de
dc.identifier.ppn	870025139

Dateien

Name:Ambrozkiewicz_Dissertation_Word.pdf

Größe:9.275Mb

Format:PDF

Öffnen

Name:: Ambrozkiewicz_Dissertation_Word.pdf
Größe:: 9.275Mb
Format:: PDF

Öffnen

Das Dokument erscheint in:

Fakultät für Biologie und Psychologie (inkl. GAUSS) [1621]

Zur Kurzanzeige