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dc.contributor.advisor Brose, Nils Prof. Dr.
dc.contributor.author Ambrozkiewicz, Mateusz Cyryl
dc.date.accessioned 2016-10-11T08:08:42Z
dc.date.available 2016-10-11T08:08:42Z
dc.date.issued 2016-10-11
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7C1D-5
dc.language.iso eng de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 570 de
dc.title HECT-type Ubiquitin Ligases in Nerve Cell Development de
dc.type doctoralThesis de
dc.contributor.referee Stegmüller, Judith Dr.
dc.date.examination 2015-11-19
dc.description.abstracteng Development of neurons begins in the middle of embryogenesis after closure of the neural tube. In the process of neurogenesis, neural stem cells generate nerve cells by asymmetric cell divisions at the ventricular zone of the brain. Immature neurons embark for their destination and start projecting axons and dendrites during migration. Growing axons are guided across the embryo towards their target neurons, and upon synaptogenesis and synapse elimination create complex architecture of the neural networks. Emerging evidence unveils that posttranslational modification by protein ubiquitylation and posttranscriptional regulation of gene expression by microRNAs are of particular importance for the nerve cell development. In this study, we demonstrate the roles of HECT-type ubiquitin ligases in newborn and mature nerve cells. Additionally, we characterize intronic microRNA and its host gene encoding for HECT-type ubiquitin ligase in developing nerve cells. Our work provides novel molecular insights for nerve cell development and contributes to present understanding of molecular cellular pathologies in intellectual disability syndrome. de
dc.contributor.coReferee Mansouri, Ahmed Prof. Dr.
dc.subject.eng Ubiquitin de
dc.subject.eng Development de
dc.subject.eng HECT de
dc.subject.eng Neuronal Migration de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C1D-5-3
dc.affiliation.institute Biologische Fakultät für Biologie und Psychologie de
dc.subject.gokfull Biologie (PPN619462639) de
dc.identifier.ppn 870025139

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