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dc.contributor.advisor Winterhalter, Michael Prof. Dr.
dc.contributor.author Freifrau von Saß, Nora
dc.date.accessioned 2016-11-09T10:17:11Z
dc.date.available 2016-11-29T23:50:06Z
dc.date.issued 2016-11-09
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7C96-2
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Anwendungsbeobachtung der Multiplate®­Impedanzaggregometrie in Bezug auf den postoperativen Transfusionsbedarf bei kardiochirurgischen Operationen mit intraoperativem Anschluss an eine Herz­Lungen­Maschine de
dc.type doctoralThesis de
dc.title.translated Use of the Multiplate® Method in Cardiothoracic Surgery with intraoperative Cardio-Pulmonary Bypass with respect to postoperative Transfusion Requirements de
dc.contributor.referee Winterhalter, Michael Prof. Dr.
dc.date.examination 2016-11-21
dc.description.abstracteng The Multiplate® System as a Point of Care method allows a standardised detection of a deficiency in platelet function in the intraoperative setting. This observational study evaluated the alteration in platelet function, as detected by the Multiplate® System, in on-pump cardiac surgeries and its predictive value with respect to postoperative transfusion demands. The study cohort consists of 82 patients. At three specific times during surgery (induction of anaesthesia, release of aortic cross clamp and after Protamine) blood samples were taken and analysed. In summary, the Multiplate® method showed a predicitive aspect with concerning administered units of Fresh Frozen Plasma, Platelet Transfusions and Coagulation Factors (PPSB and Fibrogammin) in the postoperative setting. There was no predictive aspect with respect to the postoperative administration of Packed Red Blood Cells. A combination of TRAP AUC and standard coagulation tests (PTT, Quick - Value, Fibrinogen, Thrombin-Time) can help to determine postoperative transfusion requirements. de
dc.contributor.coReferee Riggert, Joachim PD Dr.
dc.contributor.thirdReferee Mausberg, Rainer Prof. Dr.
dc.subject.ger Multiplate-Impedanzaggregometrie de
dc.subject.ger kardiovaskuläre Operationen mit intraoperativen Anschluss an die Herz-Lungen-Maschine de
dc.subject.ger POC-Methode de
dc.subject.ger postoperativer GFP- und TK-Transfusionsbedarf de
dc.subject.eng Multiplate® Method de
dc.subject.eng on-pump cardiac surgeries de
dc.subject.eng TRAP AUC de
dc.subject.eng postoperativeTransfusions de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C96-2-9
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.subject.gokfull Anästhesiologie / Intensivmedizin / Notfallmedizin / Analgesie - Allgemein- und Gesamtdarstellungen (PPN619875917) de
dc.subject.gokfull Chirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968) de
dc.description.embargoed 2016-11-28
dc.identifier.ppn 87233466X

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