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Anwendungsbeobachtung der Multiplate®­Impedanzaggregometrie in Bezug auf den postoperativen Transfusionsbedarf bei kardiochirurgischen Operationen mit intraoperativem Anschluss an eine Herz­Lungen­Maschine

dc.contributor.advisorWinterhalter, Michael Prof. Dr.
dc.contributor.authorFreifrau von Saß, Nora
dc.date.accessioned2016-11-09T10:17:11Z
dc.date.available2016-11-29T23:50:06Z
dc.date.issued2016-11-09
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002B-7C96-2
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5969
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleAnwendungsbeobachtung der Multiplate®­Impedanzaggregometrie in Bezug auf den postoperativen Transfusionsbedarf bei kardiochirurgischen Operationen mit intraoperativem Anschluss an eine Herz­Lungen­Maschinede
dc.typedoctoralThesisde
dc.title.translatedUse of the Multiplate® Method in Cardiothoracic Surgery with intraoperative Cardio-Pulmonary Bypass with respect to postoperative Transfusion Requirementsde
dc.contributor.refereeWinterhalter, Michael Prof. Dr.
dc.date.examination2016-11-21
dc.description.abstractengThe Multiplate® System as a Point of Care method allows a standardised detection of a deficiency in platelet function in the intraoperative setting. This observational study evaluated the alteration in platelet function, as detected by the Multiplate® System, in on-pump cardiac surgeries and its predictive value with respect to postoperative transfusion demands. The study cohort consists of 82 patients. At three specific times during surgery (induction of anaesthesia, release of aortic cross clamp and after Protamine) blood samples were taken and analysed. In summary, the Multiplate® method showed a predicitive aspect with concerning administered units of Fresh Frozen Plasma, Platelet Transfusions and Coagulation Factors (PPSB and Fibrogammin) in the postoperative setting. There was no predictive aspect with respect to the postoperative administration of Packed Red Blood Cells. A combination of TRAP AUC and standard coagulation tests (PTT, Quick - Value, Fibrinogen, Thrombin-Time) can help to determine postoperative transfusion requirements.de
dc.contributor.coRefereeRiggert, Joachim PD Dr.
dc.contributor.thirdRefereeMausberg, Rainer Prof. Dr.
dc.subject.gerMultiplate-Impedanzaggregometriede
dc.subject.gerkardiovaskuläre Operationen mit intraoperativen Anschluss an die Herz-Lungen-Maschinede
dc.subject.gerPOC-Methodede
dc.subject.gerpostoperativer GFP- und TK-Transfusionsbedarfde
dc.subject.engMultiplate® Methodde
dc.subject.engon-pump cardiac surgeriesde
dc.subject.engTRAP AUCde
dc.subject.engpostoperativeTransfusionsde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002B-7C96-2-9
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.subject.gokfullAnästhesiologie / Intensivmedizin / Notfallmedizin / Analgesie - Allgemein- und Gesamtdarstellungen (PPN619875917)de
dc.subject.gokfullChirurgie - Allgemein- und Gesamtdarstellungen (PPN619875968)de
dc.description.embargoed2016-11-28
dc.identifier.ppn87233466X


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