Psychopharmakotherapie in der stationären Medikamentenentzugsbehandlung - eine retrospektive Untersuchung der psychiatrischen Behandlungspraxis

Psychopharmacotherapy in the withdrawal treatment of inpatients with substance use disorder

by Teresa Giller
Doctoral thesis
Date of Examination:2016-11-15
Date of issue:2016-11-10
Advisor:PD Dr. Dirk Wedekind
Referee:Prof. Dr. Bernd Alt-Epping
Referee:Prof. Dr. Thomas Meyer
Persistent Address: http://dx.doi.org/10.53846/goediss-5936

 

 

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Abstract

English

Despite the high clinical relevance, established guidelines for benzodiazepine-, and in particular opioid addiction are still scarce. In a retrospective design, treatment variables of inpatients with benzodiazepine- and opioid-addiction or abuse were recorded according to patients´ charts. Groups comprising patients with benzodiazepine/non-benzodiazepine abuse/addiction, opioid- and non-opioid analgetic abuse/addiction were established. 92% of all patients actually received additional pharmacologic treatment. Before all, antidepressants were prescribed (76%), but also mood-stabilizers/anticonvulsants (27%), and neuroleptic drugs (11%). Antidepressant treatment was tricyclic/tetracyclic treatment almost exclusively. Anticonvulsants, in most cases carbamazepine, was mostly prescribed for patients with combined drug use or high-dose benzodiazepine addiction, who were significantly more often treated with anticonvulsants compared to low-dose addicted subjects. Despite a negative recommendation according to AWMF-guidelines for medication addiction, low potential neuroleptic drugs were used frequently in all patient groups. 80% of included subjects had at least one comorbid psychiatric condition, before all depressive disorder, anxiety disorders, PTSD, and other adjustment disorders. 67% of patients described traumatic life-events. These were significantly more often found in high-dose compared to low dose benzodiazepine addicted patients.
Keywords: substance; opioid; addiction; benzodiazepine; non-benzodiazepine; abuse; non-opioid; withdrawal; psychopharmacotherapy
Schlagwörter: Benzodiazepin; Opioidanalgetika; Nichtopioidanalgetika; Psychopharmakotherapie; stationäre; Medikamentenentzugsbehandlung; Entzug; Entzugsbehandlung
 
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