| dc.contributor.advisor | Nauck, Michael Prof. Dr. | |
| dc.contributor.author | Becht, Florian Sebastian | |
| dc.date.accessioned | 2016-11-11T09:19:07Z | |
| dc.date.available | 2016-12-13T23:50:05Z | |
| dc.date.issued | 2016-11-11 | |
| dc.identifier.uri | http://hdl.handle.net/11858/00-1735-0000-002B-7CA2-6 | |
| dc.identifier.uri | http://dx.doi.org/10.53846/goediss-5951 | |
| dc.language.iso | deu | de |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.ddc | 610 | de |
| dc.title | Nüchtern - C - Peptid und daraus abgeleitete Parameter zur Charakterisierung der Insulin - Kapazität zwecks korrekter Klassifizierung von Patienten mit Typ 1 - und Typ 2 - Diabetes und zur Vorhersagekraft einer Insulinpflichtigkeit bei Patienten mit Typ 2 - Diabetes | de |
| dc.type | doctoralThesis | de |
| dc.title.translated | Fasting C-peptide and related parameters characterizing insulin secretory capacity for correctly classifying diabetes type and for predicting insulin requirement in patients with type 2 diabetes | de |
| dc.contributor.referee | Raddatz, Dirk Prof. Dr. | |
| dc.date.examination | 2016-12-06 | |
| dc.description.abstracteng | BACKGROUND/AIMS:
C-peptide allows estimation of insulin secretion even in the presence of insulin treatment. C-peptide may be suitable for the differential diagnosis of type 1 and type 2 diabetes, and, within type 2 diabetes, of insulin-requiring vs. non-insulin-requiring patients. Relating C-peptide concentrations to ambient glucose levels might improve its diagnostic potential.
PATIENTS/METHODS:
The diagnostic value (a) fasting C-peptide, (b) C-peptide/glucose ratios, and (c) the HOMA-ßC-peptide-index for predicting a diagnosis of type 1 (vs. type 2) diabetes were assessed.
SETTING:
Specialised hospital for the care of diabetic patients (inpatient treatment). 303 patients with type 1 diabetes and 841 patients with type 2 diabetes.
MAIN OUTCOME MEASURE:
Odds ratios and 95% confidence intervals for a clinical diagnosis of type 1 diabetes or for insulin treatment by deciles of (a) fasting C-peptide, (b) C-peptide/glucose ratios, and (c) HOMA-ßC-peptide-index.
RESULTS:
Low C-peptide concentrations were associated with a high odds ratio for type 1 diabetes and vice versa (p<0.0001). Concentrations of 0.13-0.36 nmol/l did not discriminate. C-peptide/glucose ratios or HOMA-ßC-Peptide did not perform better. The ability of all 3 parameters to predict the necessity for insulin treatment within the population of type 2-diabetic patients was low.
CONCLUSIONS:
Fasting C-peptide and derived parameters help to differentiate type 1 from type 2 diabetes, but there is a range of C-peptide concentrations that does not help discriminate. Relating C-peptide to glucose did not improve diagnostic accuracy. C-peptide does not help predicting a need for insulin treatment in patients with type 2 diabetes. | de |
| dc.contributor.coReferee | Oppermann, Martin Prof. Dr. | |
| dc.subject.ger | C-Peptid | de |
| dc.subject.ger | nüchtern-C-Peptid | de |
| dc.subject.ger | C-Peptid/Glukose-Verhältnis | de |
| dc.subject.ger | Homa-ßC-Peptid-Index | de |
| dc.subject.ger | Typ 1 Diabetes | de |
| dc.subject.ger | Typ 2 Diabetes | de |
| dc.subject.ger | Insulinpflicht | de |
| dc.subject.eng | C-peptide | de |
| dc.subject.eng | fasting C-peptide | de |
| dc.subject.eng | C-peptide/glucose ratio | de |
| dc.subject.eng | HOMA-ßC-peptide-index | de |
| dc.subject.eng | type 1 diabetes | de |
| dc.subject.eng | type 2 diabetes | de |
| dc.subject.eng | predicting insulin treatment | de |
| dc.identifier.urn | urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7CA2-6-1 | |
| dc.affiliation.institute | Medizinische Fakultät | de |
| dc.subject.gokfull | Innere Medizin - Allgemein- und Gesamtdarstellungen (PPN619875747) | de |
| dc.description.embargoed | 2016-12-13 | |
| dc.identifier.ppn | 872365344 | |