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dc.contributor.advisor Lotz, Joachim Prof. Dr.
dc.contributor.author Rosenberg, Christina
dc.date.accessioned 2016-11-18T07:43:22Z
dc.date.available 2016-12-06T23:50:05Z
dc.date.issued 2016-11-18
dc.identifier.uri http://hdl.handle.net/11858/00-1735-0000-002B-7CAF-C
dc.language.iso deu de
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc 610 de
dc.title Korrelation von Volumen des rechten Vorhofs mit dem Auftreten von supraventrikulären und ventrikulären Arrhythmien bei Patienten mit korrigerter Fallot-Tetralogie de
dc.type doctoralThesis de
dc.title.translated Right Atrial Volume is increased in corrected Tetralogy of Fallot and correlates with the incidence of Supraventricular Arrhythmia de
dc.contributor.referee Sigler, Matthias Prof. Dr.
dc.date.examination 2016-11-29
dc.description.abstracteng The aim of this study was to evaluate right atrial (RA) volume in corrected Tetralogy of Fallot (cTOF) and assess its correlation with the occurrence of supraventricular (SV) arrhythmia. Cardiac magnetic reso- nance imaging (CMR) and 24-h Holter were performed in n = 67 consecutive cTOF patients (age 30 ± 11.3 years). The CMR protocol included standard HASTE, SSFP cine, and blood flow measurements. Correlations between ar- rhythmia in ECG, heart volume, and functional parameters were investigated by negative binominal regression. Pa- tients’ characteristics (mean ± SD) included mean RA volume of 49 ± 19 ml/m2 (HASTE sequence), mean right ventricular (RV) end-diastolic volume of 98 ± 27 ml/m2, mean pulmonary valve regurgitation fraction (PR) of 21 ± 19 %, BMI of 25 kg/m2, and heart rate of 75/min. Twenty-eight out of 67 patients experienced SV arrhythmia including SV couplets or bigeminus or longer non-sus- tained SV tachycardia (SVT) episodes. RA volume index was identified as an independent risk factor for different degrees of SV arrhythmia (SV couplets/bigeminus p <0.001, SVT p <0.001). Further risk factors for SV arrhythmia were male gender (p = 0.023) and decreased left ventricular (LV) ejection fraction (EF) (LV EF p < 0.001). RA volume is increased in adult patients with cTOF with larger RA volumes relating to higher incidence of SV arrhythmia. SV arrhythmia also appeared more often in male patients and those with decreased LV EF. Risk stratification according to these parameters could help to optimize early prevention and adjusted individual therapy to improve patient outcome and quality of life. de
dc.contributor.coReferee Oppermann, Martin Prof. Dr.
dc.subject.ger Fallot-Tetralogie de
dc.subject.ger Arrhythmien de
dc.subject.ger angeborener Herzfehler de
dc.subject.ger MRT de
dc.subject.ger Kinderkardiologie de
dc.subject.ger Pädiatrie de
dc.subject.eng Tetralogy of Fallot de
dc.subject.eng Arrhythmia de
dc.subject.eng congenital heart failure de
dc.subject.eng Pediatric cardiology de
dc.subject.eng MRI de
dc.subject.eng follow up de
dc.identifier.urn urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7CAF-C-1
dc.affiliation.institute Medizinische Fakultät de
dc.subject.gokfull Medizin (PPN619874732) de
dc.description.embargoed 2016-12-06
dc.identifier.ppn 872808122

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