Korrelation von Volumen des rechten Vorhofs mit dem Auftreten von supraventrikulären und ventrikulären Arrhythmien bei Patienten mit korrigerter Fallot-Tetralogie

Rosenberg, Christina

dc.contributor.advisor	Lotz, Joachim Prof. Dr.
dc.contributor.author	Rosenberg, Christina
dc.date.accessioned	2016-11-18T07:43:22Z
dc.date.available	2016-12-06T23:50:05Z
dc.date.issued	2016-11-18
dc.identifier.uri	http://hdl.handle.net/11858/00-1735-0000-002B-7CAF-C
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5981
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5981
dc.identifier.uri	http://dx.doi.org/10.53846/goediss-5981
dc.language.iso	deu	de
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc	610	de
dc.title	Korrelation von Volumen des rechten Vorhofs mit dem Auftreten von supraventrikulären und ventrikulären Arrhythmien bei Patienten mit korrigerter Fallot-Tetralogie	de
dc.type	doctoralThesis	de
dc.title.translated	Right Atrial Volume is increased in corrected Tetralogy of Fallot and correlates with the incidence of Supraventricular Arrhythmia	de
dc.contributor.referee	Sigler, Matthias Prof. Dr.
dc.date.examination	2016-11-29
dc.description.abstracteng	The aim of this study was to evaluate right atrial (RA) volume in corrected Tetralogy of Fallot (cTOF) and assess its correlation with the occurrence of supraventricular (SV) arrhythmia. Cardiac magnetic reso- nance imaging (CMR) and 24-h Holter were performed in n = 67 consecutive cTOF patients (age 30 ± 11.3 years). The CMR protocol included standard HASTE, SSFP cine, and blood flow measurements. Correlations between ar- rhythmia in ECG, heart volume, and functional parameters were investigated by negative binominal regression. Pa- tients’ characteristics (mean ± SD) included mean RA volume of 49 ± 19 ml/m2 (HASTE sequence), mean right ventricular (RV) end-diastolic volume of 98 ± 27 ml/m2, mean pulmonary valve regurgitation fraction (PR) of 21 ± 19 %, BMI of 25 kg/m2, and heart rate of 75/min. Twenty-eight out of 67 patients experienced SV arrhythmia including SV couplets or bigeminus or longer non-sus- tained SV tachycardia (SVT) episodes. RA volume index was identified as an independent risk factor for different degrees of SV arrhythmia (SV couplets/bigeminus p <0.001, SVT p <0.001). Further risk factors for SV arrhythmia were male gender (p = 0.023) and decreased left ventricular (LV) ejection fraction (EF) (LV EF p < 0.001). RA volume is increased in adult patients with cTOF with larger RA volumes relating to higher incidence of SV arrhythmia. SV arrhythmia also appeared more often in male patients and those with decreased LV EF. Risk stratification according to these parameters could help to optimize early prevention and adjusted individual therapy to improve patient outcome and quality of life.	de
dc.contributor.coReferee	Oppermann, Martin Prof. Dr.
dc.subject.ger	Fallot-Tetralogie	de
dc.subject.ger	Arrhythmien	de
dc.subject.ger	angeborener Herzfehler	de
dc.subject.ger	MRT	de
dc.subject.ger	Kinderkardiologie	de
dc.subject.ger	Pädiatrie	de
dc.subject.eng	Tetralogy of Fallot	de
dc.subject.eng	Arrhythmia	de
dc.subject.eng	congenital heart failure	de
dc.subject.eng	Pediatric cardiology	de
dc.subject.eng	MRI	de
dc.subject.eng	follow up	de
dc.identifier.urn	urn:nbn:de:gbv:7-11858/00-1735-0000-002B-7CAF-C-1
dc.affiliation.institute	Medizinische Fakultät	de
dc.subject.gokfull	Medizin (PPN619874732)	de
dc.description.embargoed	2016-12-06
dc.identifier.ppn	872808122

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