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Korrelation von Volumen des rechten Vorhofs mit dem Auftreten von supraventrikulären und ventrikulären Arrhythmien bei Patienten mit korrigerter Fallot-Tetralogie

dc.contributor.advisorLotz, Joachim Prof. Dr.
dc.contributor.authorRosenberg, Christina
dc.date.accessioned2016-11-18T07:43:22Z
dc.date.available2016-12-06T23:50:05Z
dc.date.issued2016-11-18
dc.identifier.urihttp://hdl.handle.net/11858/00-1735-0000-002B-7CAF-C
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5981
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5981
dc.identifier.urihttp://dx.doi.org/10.53846/goediss-5981
dc.language.isodeude
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610de
dc.titleKorrelation von Volumen des rechten Vorhofs mit dem Auftreten von supraventrikulären und ventrikulären Arrhythmien bei Patienten mit korrigerter Fallot-Tetralogiede
dc.typedoctoralThesisde
dc.title.translatedRight Atrial Volume is increased in corrected Tetralogy of Fallot and correlates with the incidence of Supraventricular Arrhythmiade
dc.contributor.refereeSigler, Matthias Prof. Dr.
dc.date.examination2016-11-29
dc.description.abstractengThe aim of this study was to evaluate right atrial (RA) volume in corrected Tetralogy of Fallot (cTOF) and assess its correlation with the occurrence of supraventricular (SV) arrhythmia. Cardiac magnetic reso- nance imaging (CMR) and 24-h Holter were performed in n = 67 consecutive cTOF patients (age 30 ± 11.3 years). The CMR protocol included standard HASTE, SSFP cine, and blood flow measurements. Correlations between ar- rhythmia in ECG, heart volume, and functional parameters were investigated by negative binominal regression. Pa- tients’ characteristics (mean ± SD) included mean RA volume of 49 ± 19 ml/m2 (HASTE sequence), mean right ventricular (RV) end-diastolic volume of 98 ± 27 ml/m2, mean pulmonary valve regurgitation fraction (PR) of 21 ± 19 %, BMI of 25 kg/m2, and heart rate of 75/min. Twenty-eight out of 67 patients experienced SV arrhythmia including SV couplets or bigeminus or longer non-sus- tained SV tachycardia (SVT) episodes. RA volume index was identified as an independent risk factor for different degrees of SV arrhythmia (SV couplets/bigeminus p <0.001, SVT p <0.001). Further risk factors for SV arrhythmia were male gender (p = 0.023) and decreased left ventricular (LV) ejection fraction (EF) (LV EF p < 0.001). RA volume is increased in adult patients with cTOF with larger RA volumes relating to higher incidence of SV arrhythmia. SV arrhythmia also appeared more often in male patients and those with decreased LV EF. Risk stratification according to these parameters could help to optimize early prevention and adjusted individual therapy to improve patient outcome and quality of life.de
dc.contributor.coRefereeOppermann, Martin Prof. Dr.
dc.subject.gerFallot-Tetralogiede
dc.subject.gerArrhythmiende
dc.subject.gerangeborener Herzfehlerde
dc.subject.gerMRTde
dc.subject.gerKinderkardiologiede
dc.subject.gerPädiatriede
dc.subject.engTetralogy of Fallotde
dc.subject.engArrhythmiade
dc.subject.engcongenital heart failurede
dc.subject.engPediatric cardiologyde
dc.subject.engMRIde
dc.subject.engfollow upde
dc.identifier.urnurn:nbn:de:gbv:7-11858/00-1735-0000-002B-7CAF-C-1
dc.affiliation.instituteMedizinische Fakultätde
dc.subject.gokfullMedizin (PPN619874732)de
dc.description.embargoed2016-12-06
dc.identifier.ppn872808122


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