Angiopoietin-2 — ein neuer Biomarker bei Patienten mit akuter Lungenembolie

Angiopoietin-2 — a novel biomarker in patients with pulmonary embolism

by Caroline Niemann
Doctoral thesis
Date of Examination:2016-12-08
Date of issue:2016-11-28
Advisor:Mareike Katharina Lankeit
Referee:Mareike Katharina Lankeit
Referee:Prof. Dr. Daniel Patschan
Persistent Address: http://dx.doi.org/10.53846/goediss-5995

 

 

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Abstract

English

Angiopoietin-2 (Ang-2), an antagonist ligand of the endothelial-specific Tie2 receptor, inhibits the stabilizing influence of the Tie2 activator Ang-1, thereby promoting vascular remodeling. Elevated levels of Ang-2 are associated with impaired hemodynamic parameters and poor prognosis in patients with idiopathic pulmonary hypertension. This thesis aimed to investigate the prognostic value of Ang-2 in patients with acute pulmonary embolism (PE).
Keywords: pulmonary embolism; Angiopoietin-2; CTEPH
Schlagwörter: Lungenembolie; Angiopoietin-2; CTEPH
 
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