Angiopoietin-2 — ein neuer Biomarker bei Patienten mit akuter Lungenembolie

Angiopoietin-2 — ein neuer Biomarker bei Patienten mit akuter Lungenembolie

Angiopoietin-2 — a novel biomarker in patients with pulmonary embolism

Caroline Niemann

Doctoral thesis

Date of Examination: 2016-12-08

Date of issue: 2016-11-28

Advisor: Lankeit, Mareike Katharina

Referee: Lankeit, Mareike Katharina

Referee: Patschan, Daniel Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-002B-7CBE-A

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Abstract

English

Angiopoietin-2 (Ang-2), an antagonist ligand of the endothelial-specific Tie2 receptor, inhibits the stabilizing influence of the Tie2 activator Ang-1, thereby promoting vascular remodeling. Elevated levels of Ang-2 are associated with impaired hemodynamic parameters and poor prognosis in patients with idiopathic pulmonary hypertension. This thesis aimed to investigate the prognostic value of Ang-2 in patients with acute pulmonary embolism (PE).

Keywords: pulmonary embolism; Angiopoietin-2; CTEPH

Schlagwörter: Lungenembolie; Angiopoietin-2; CTEPH