Einfluss der Ca2+/Calmodulin-abhängigen Proteinkinase II delta auf den L-Typ Ca2+-Strom -Untersuchungen anhand eines genetischen Knock-outs im Mausmodell

Einfluss der Ca2+/Calmodulin-abhängigen Proteinkinase II delta auf den L-Typ Ca2+-Strom -Untersuchungen anhand eines genetischen Knock-outs im Mausmodell

Influence of ca2+/calmodulin-dependent kinase II delta on l-type ca2+-current - investigations using a knockout model in mice

Neuhaus, Victor

Doctoral thesis

Date of Examination: 2016-12-20

Date of issue: 2016-12-20

Advisor: Maier, Lars Prof. Dr.

Referee: Schwappach-Pignataro, Blanche Prof. Dr.

Referee: Oppermann, Martin Prof. Dr.

Persistent Address: http://hdl.handle.net/11858/00-1735-0000-002B-7CEA-8

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Abstract

English

Ca2+/calmodulin-dependent kinase II delta plays an important role in heart failure as activity and expression of the kinase are higher in myocytes of failing hearts. In this dissertation transverse aortic constriction led to cardiac hypertrophy and increase of l-type ca2+-current in murine myocytes. Inhibition of ca2+/calmodulin-dependent kinase II delta using autocamtide-2-related inhibitory peptide and genetic knockout normalized l-type ca2+-current.

Keywords: ca2+/calmodulin-dependent kinase II delta